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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations blaL2F72I

beta-lactamase

Protein ChangeF72I

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced resistance
Resistance To: Cephalexin|Cefazolin|Cefoxitin|Ceftazidime|Ceftriaxone|Cefepime|Aztreonam|Meropenem|Imipenem, Ceftazidime|Cephalexin|Aztreonam
Organisms: Escherichia coli, Stenotrophomonas maltophilia
Papers: 1

Paper Information1

1

The continued evolution of the L2 cephalosporinase in Stenotrophomonas maltophilia: a key driver of beta-lactam resistance.

PMID 39804574 · 2025

The Phe72Ile mutation leads to decreased resistance, whereas the Ile72Phe mutation enhances resistance.

Mutation Information

Protein Change: F72I
Organisms: Escherichia coli, Stenotrophomonas maltophilia
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Cephalexin|Cefazolin|Cefoxitin|Ceftazidime|Ceftriaxone|Cefepime|Aztreonam|Meropenem|Imipenem

Ceftazidime|Cephalexin|Aztreonam

Effect on Function

reduced resistance

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research