The study identifies a novel metallo-beta-lactamase gene, blaNDM-1, and a new erythromycin esterase gene, ereC, in a carbapenem-resistant Klebsiella pneumoniae isolate from India. Both genes were experimentally validated for their roles in antibiotic resistance.

The study reports the first identification of a patient colonized with Klebsiella pneumoniae carrying the blaNDM-1 gene in Taiwan, highlighting the significance of monitoring and controlling the spread of such resistant bacteria.

The study focuses on the detection of NDM-1 producers, highlighting the importance of identifying these strains for infection control. It describes methods for detecting NDM-1, including PCR, susceptibility testing, and the use of specific culture media.

The paper describes the identification and characterization of the novel metallo-beta-lactamase NDM-1, which confers resistance to a wide range of beta-lactam antibiotics, including carbapenems.

The study reports the isolation of multidrug-resistant Klebsiella pneumoniae and Escherichia coli isolates carrying the New Delhi metallo-beta-lactamase (NDM-1) gene in Canada, highlighting the potential public health threat posed by this resistance mechanism.

The study reports the emergence of NDM-1-positive K. pneumoniae in Austria, highlighting the resistance to nearly all antibacterial agents except colistin, tigecycline, and amikacin.

The study identifies the New Delhi Metallo-β-lactamase (NDM-1) as a cause of carbapenem resistance in Klebsiella pneumoniae, highlighting its rapid spread and clinical significance.

The study reports the isolation of an Escherichia coli strain carrying the blaNDM-1 gene, which confers resistance to carbapenems. The isolate was recovered from a patient who had recently been hospitalized in India and highlights the global spread of antimicrobial resistance through international travel.

The study reports the detection and characterization of a New Delhi metallo-beta-lactamase (NDM-1)-producing K. pneumoniae isolate in Ontario, Canada, highlighting its resistance to multiple antibiotics including carbapenems, cephalosporins, and penicillins.

The study reports the first case of a Klebsiella pneumoniae isolate harboring the NDM-1 metallo-beta-lactamase in the United States, highlighting its resistance to all β-lactam antibiotics except aztreonam.

The study reports the emergence of NDM-1-producing Enterobacteriaceae in Belgium, highlighting the presence of multiple resistance mechanisms including blaNDM-1, qnrA6, qnrB1, qnrB2, and various beta-lactamases, rRNA methylases, and quinolone resistance genes.

The study reports the complete sequencing of the plasmid pNDM-HK, which encodes the NDM-1 carbapenemase. The plasmid contains multiple resistance genes, including blaNDM-1, aacC2, armA, and blaTEM-1, contributing to resistance against carbapenems, aminoglycosides, and beta-lactams.

The study identifies the first locally acquired case of New Delhi metallo-β-lactamase-1 (NDM-1) in Canada, highlighting its resistance to carbapenems and other beta-lactam antibiotics, and discusses challenges in detection.

The study reports the early detection of VIM-1-producing Klebsiella pneumoniae and NDM-1-producing Escherichia coli in two children returning to France, highlighting the importance of identifying metallo-beta-lactamase-producing organisms for effective infection control.

The study identifies the blaNDM-1 gene as a prevalent carbapenemase in Enterobacteriaceae isolates from India, highlighting its association with multidrug resistance and the need for improved surveillance.

The study developed a real-time PCR assay for the detection of blaNDM-1 genes in spiked stool samples, demonstrating high sensitivity and specificity for identifying NDM-1 carbapenemase producers.

The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.

The study developed a TaqMan real-time PCR assay for detecting the blaNDM-1 gene, which confers resistance to carbapenems in clinical isolates of E. coli, K. pneumoniae, and A. baumannii.

NDM-1 is a metallo-beta-lactamase that confers resistance to carbapenems and other beta-lactam antibiotics. It exhibits potent hydrolytic activity against these antibiotics, making it a significant threat in clinical settings.

The study identifies a novel variant of the New Delhi metallo-beta-lactamase, NDM-5, which confers resistance to carbapenems and cephalosporins in a multidrug-resistant E. coli ST648 isolate.

The study characterizes the NDM-1 metallo-beta-lactamase, which confers resistance to carbapenems and other beta-lactam antibiotics.

The study reports the complete sequence of the IncA/C plasmid pNDM-1_Dok01 carrying the blaNDM-1 gene, which confers resistance to carbapenems. The plasmid was found to be associated with IS903 elements and includes chaperonin genes groES and groEL, suggesting a possible origin from plant pathogens.

This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.

The study reports the emergence of NDM-1 and KPC-2 carbapenemases in K. pneumoniae and E. cloacae in South Africa, highlighting their association with multidrug resistance and the need for improved detection strategies.

The study identifies NDM-4, a novel metallo-beta-lactamase with increased carbapenemase activity, differing from NDM-1 by a single amino acid substitution (Met154Leu).

The study identifies blaCTX-M-62 and blaNDM-1 as resistance genes in plasmids pJIE137 and p271A, respectively, highlighting their role in resistance to extended-spectrum beta-lactams and carbapenems.

The study identifies and characterizes various carbapenemases, including blaIMP, blaVIM, blaNDM-1, blaKPC, and blaOXA-48, in carbapenem-resistant Enterobacteriaceae through phenotypic testing with inhibitor-impregnated agar.

The study reports the complete sequences of a blaNDM-1-bearing plasmid, pNDM-BJ01, and its variant, pNDM-BJ02, isolated from clinical Acinetobacter lwoffii strains. Both plasmids contain the blaNDM-1 gene, which confers resistance to carbapenems.

The study identifies a novel 178-kilobase plasmid carrying the blaNDM-1 gene in a Providencia stuartii strain, highlighting the spread of carbapenem resistance.

The paper discusses the mechanisms of resistance to β-lactams, glycopeptides, and fluoroquinolones, highlighting the role of beta-lactamases such as TEM, SHV, CTX-M, KPC, VIM, and NDM, glycopeptide resistance operons like vanA and vanB, and other resistance genes such as ermB, mecA, qnrA, and aac(6')-Ib.

The study describes a loop-mediated isothermal amplification (LAMP) assay for the rapid detection of the blaNDM-1 gene, which confers resistance to carbapenems. The LAMP assay was found to be more sensitive than PCR and effective in detecting blaNDM-1 in various clinical samples.

The study identified blaNDM and blaVIM genes as the primary mechanisms of carbapenem resistance in E. coli and K. pneumoniae isolates.

The study reports the identification of NDM-1-producing Klebsiella pneumoniae in Croatia, highlighting the spread of this carbapenem-resistant strain beyond the Indian subcontinent.

The study identifies the emergence of multidrug-resistant NDM-1-producing Gram-negative bacteria in Bangladesh, highlighting the prevalence of blaNDM-1 among clinical isolates and the coexistence of other resistance genes.

The study reports the identification of NDM-1-producing Klebsiella pneumoniae strains resistant to colistin in a French community patient without a history of foreign travel, highlighting the emergence of multidrug-resistant strains.

The study characterizes an IncFII plasmid carrying the blaNDM-1 gene, along with other resistance genes such as aacA4, aadA2, aacC2, and blaOXA-1, which contribute to multidrug resistance in E. coli ST131.

The paper discusses the emergence of NDM-1, a carbapenemase enzyme encoded by the blaNDM-1 gene, which confers resistance to carbapenems in Enterobacteriaceae. It highlights the challenges in diagnosing and treating infections caused by NDM-1-producing bacteria and emphasizes the public health concerns associated with its spread.

The paper discusses various virulence factors and mechanisms contributing to the pathogenicity and antibiotic resistance of Acinetobacter baumannii, including biofilm formation, surface polysaccharides, and outer membrane proteins.

The study identifies the bla NDM-1 gene in Acinetobacter lwoffii isolated from a chicken, which confers resistance to carbapenems and other β-lactams.

The paper discusses the emergence and spread of carbapenem-resistant Enterobacteriaceae, particularly highlighting the NDM-1 gene, which confers resistance to carbapenems. It provides an overview of the epidemiology and mechanisms of resistance in Lebanon and neighboring countries.

The study identified the blaNDM-1 gene in Acinetobacter baumannii, which confers resistance to carbapenems. Structural analysis and molecular docking studies provided insights into the antibiotic binding interactions of blaNDM-1.

The study reports the detection of bla(NDM-1)-positive Klebsiella pneumoniae in the environment in Vietnam, highlighting the presence of this gene in multiple isolates and their resistance to various antimicrobial agents.

The study reports the isolation of a third-generation cephalosporin-resistant Vibrio cholerae strain carrying the blaDHA-1 and blaNDM-1 genes, which confer resistance to ceftriaxone and carbapenems respectively.

The study describes a quick and easy method for detecting NDM-1 producers in clinical isolates, highlighting the importance of rapid identification of carbapenem-resistant organisms.

A novel metallo-beta-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

The paper discusses the global emergence of carbapenemases, including KPC, NDM, and OXA-48, which confer resistance to carbapenems and other beta-lactam antibiotics. These enzymes are critical in the spread of multidrug-resistant Gram-negative bacteria.

The study detected the blaNDM-1 gene encoding New Delhi metallo-beta-lactamase in Acinetobacter schindleri and identified a novel class D oxacillinase, blaOXA-278, which contributes to carbapenem resistance.

The study identifies a novel NDM carbapenemase, NDM-7, in an E. coli isolate from France, which shows resistance to carbapenems and other beta-lactams.

The study characterizes the biochemical properties of NDM-1, a metallo-beta-lactamase that confers resistance to beta-lactam antibiotics. NDM-1 shows unique features compared to other MBLs, including stability at high pH and sensitivity to EDTA.

The study identifies NDM-1, OXA-23, and CTX-M-15 as the primary carbapenemases responsible for resistance in multidrug-resistant Gram-negative bacteria isolated from a Canadian patient with a history of hospitalization in India.

The study reports the molecular characterization of the blaNDM-1 gene in a Pseudomonas aeruginosa isolate from France, highlighting its chromosomal location and genetic environment.

The paper reports two cases of colonization and infection with Enterobacter cloacae strains producing New Delhi Metallo-β-lactamase 1 (NDM-1), highlighting the importation of this resistance gene into Northern Ireland.

The study identifies the blaNDM-1 gene on plasmid pKPX-1 as a key factor in carbapenem resistance in a multidrug-resistant Klebsiella pneumoniae isolate. It also characterizes additional resistance genes such as aac(6')-Ib, aac(6')-Ib-cr, aph(3')-I, strB, qnrB, tetA, catA1, and catB4, which contribute to resistance against aminoglycosides, fluoroquinolones, tetracycline, and chloramphenicol.

The study identifies the blaNDM-1 and blaOXA-94 genes as responsible for carbapenem resistance in multidrug-resistant Acinetobacter baumannii isolates from France and North Africa.

The study characterizes nine New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae isolates, including one novel allele, blaNDM-6. These isolates exhibited resistance to beta-lactams, fluoroquinolones, and aminoglycosides.

The study characterizes nine New Delhi metallo-beta-lactamase (NDM)-producing Enterobacteriaceae isolates, including one novel allele, blaNDM-6. These isolates exhibited resistance to beta-lactams, fluoroquinolones, and aminoglycosides.

The study identifies the first clinical isolate of Escherichia coli BJ01 carrying the blaNDM-1 gene in China, which confers resistance to carbapenems. Additionally, blaTEM-1 and blaCTX-M-57 genes were detected, contributing to beta-lactam resistance.

The study identified a diverse array of antibiotic resistance mechanisms in soil bacteria, including novel aac(6')-Ib variants and the absence of bla NDM-1 genes. Efflux mechanisms were found to be a major contributor to multidrug resistance.

The study identifies various beta-lactamase genes, including CTX-M-15, CTX-M-14, CTX-M-9, SHV-12, SHV-5, TEM-1, VEB-1, GES-1, GES-5, GES-11, PER-1, OXA-48, NDM-1, VIM-2, OXA-23, OXA-40, OXA-58, and OXA-181, which confer resistance to β-lactam antibiotics in Gram-negative pathogens from the Arabian Peninsula.

The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.

The study identified several antibiotic resistance genes in Achromobacter xylosoxidans NH44784-1996, including beta-lactamases, tetracycline efflux proteins, and macrolide resistance genes, indicating its resistance to various antibiotics.

The study describes a duplex real-time PCR assay for the rapid and direct detection of blaKPC and blaNDM genes in surveillance samples, demonstrating high sensitivity and specificity for identifying carbapenemase-producing Enterobacteriaceae.

The study evaluated the Xpert MDRO assay for detecting blaKPC, blaNDM, and blaVIM carbapenem resistance genes in clinical samples, demonstrating high sensitivity and specificity for identifying carbapenemase-producing organisms.

The study identified the prevalence of NDM-1-producing multidrug-resistant bacteria in two Pakistani hospitals, highlighting the significant spread of metallo-beta-lactamase genes among clinical isolates.

The study reports the first identification of NDM-1-producing Acinetobacter baumannii in East Africa, highlighting the presence of various resistance genes including bla(NDM-1), bla(OXA-23), bla(OXA-51-like), bla(ADC), armA, aadB, aac(6')-Ib, and aph(3')-VI.

The study reports the first identification of NDM-1-producing Acinetobacter baumannii in East Africa, highlighting the presence of various resistance genes including bla(NDM-1), bla(OXA-23), bla(OXA-51-like), bla(ADC), armA, aadB, aac(6')-Ib, and aph(3')-VI.

The study identified that blaCTX-M-15, blaSHV-12, blaDHA-1, ampR, blaKPC-2, and blaNDM-1 are responsible for carbapenem resistance in Klebsiella pneumoniae. The loss of porins OmpK35 and OmpK36 combined with these genes contributed to resistance against various carbapenems.

The study reports the isolation of a carbapenem-resistant Salmonella strain carrying the blaNDM-1 gene, which confers resistance to carbapenems and cephalosporins.

The SMART study analyzed antimicrobial resistance trends in Gram-negative bacilli, identifying new β-lactamase variants (blaSHV-129, blaKPC-11) and highlighting the prevalence of carbapenem resistance mechanisms such as NDM-1.

The study reports the emergence of NDM-1-producing non-baumannii Acinetobacter spp., including A. nosocomialis and A. pittii, in China. It identifies novel bla ADC genes (bla ADC-69, bla ADC-70, and bla ADC-71) and confirms the presence of bla NDM-1 on a plasmid.