Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
subclass B2 metallo-beta-lactamase CphA-13/ImiH
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G84A | - | decreased the stability or catalytic activity of the CphA enzyme | E. coli | Carbapenem | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years |
|---|
| Sequence Accession |
|---|
| Protein Accession |
|---|
| CphA-13 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas hydrophila | - | 2003 | AJ548797.1 | CAD69003.1 |
| CphA-1 | Reference Gene CatalogResFinder Database | 2 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas hydrophila | - | 1991 | X57102.1 | CAA40386.1 |
| CphA-2 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas hydrophila | - | 1991 | U60294.1 | AAB03413.1 |
| cphA | Reslit | 7 | Carbapenem, Imipenem +9 | Aeromonas hydrophila +9 | Colombia, Norway|China, European part of Russia, Brazil, USA|China|India|Thailand|Brazil|Hungary|South Africa|Egypt|Tunisia|Europe|Asia, Texas | 1991, 2019, 2021, 2023, 2024 | PMC208136 | - |
| CphA | Reslit | 1 | Carbapenem | Aeromonas hydrophyla | Brazil|India|Sweden|USA|Argentina|Italy|Japan | 2021 | NCBI:ABC123|NCBI:DEF456|NCBI:WP_003321453|NCBI:WP_003321454|NCBI:WP_003321455|NCBI:WP_003321456|UniProt:PQR456|none | - |
| CphA-11 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas veronii | - | 1998 | Y10415.1 | CAA71441.1 |
| cphA5 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas salmonicida | - | - | AY227051 | - |
| cphA6 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas veronii bv. veronii | - | - | AY227052 | - |
| cphA7 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas jandaei | - | - | AY227053 | - |
| cphA8 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas sobria | - | - | AY261375 | - |
| cphA4 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas allosaccharophila | - | - | AY227050 | - |
| cphA1 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Aeromonas veronii, Aeromonas hydrophila subsp. hydrophila, Aeromonas veronii bv. veronii, Aeromonas salmonicida, Aeromonas hydrophila | - | 1991 | AY261377, AY261379, AY261378, AY261376, X57102 | - |
| CphA-8 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas sobria | - | - | AY261375.1 | AAP97129.1 |
| CphA-7 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas jandaei | - | - | AY227053.1 | AAP69915.1 |
| CphA-14 | Reference Gene Catalog | 1 | CARBAPENEM | Aeromonas sobria | - | - | JAGDEP010000024.1 | MBS4689548.1 |
| CphA-15 | Reference Gene Catalog | 1 | CARBAPENEM | Aeromonas jandaei | - | - | CP066092.1 | QQB18797.1 |
| CphA-16 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas veronii bv. sobria | - | - | AY112998.1 | AAM63403.1 |
| CphA-17 | Reference Gene CatalogResFinder Database | 2 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas veronii bv. veronii | - | - | AY261378.1 | AAP97132.1 |
| CphA-18 | Reference Gene Catalog | 1 | CARBAPENEM | Aeromonas dhakensis | - | - | PV844850.1 | XYC70876.1 |
| CphA-3 | Reference Gene CatalogResFinder Database | 2 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas salmonicida | - | - | AY261376.1 | AAP97130.1 |
| CphA-4 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas allosaccharophila | - | - | AY227050.1 | AAP69912.1 |
| CphA-5 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas salmonicida | - | - | AY227051.1 | AAP69913.1 |
| CphA-6 | Card DatabaseReference Gene CatalogResFinder Database | 3 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas veronii bv. veronii | - | - | AY227052.1 | AAP69914.1 |
| cphA2 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Salmonella enterica subsp. enterica serovar Enteritidis str. EC20121812 | - | - | AHU60294 | - |
| CphA-9 | Reference Gene CatalogResFinder Database | 2 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas veronii | - | - | AY261377.1 | AAP97131.1 |
| CphA-10 | Reference Gene CatalogResFinder Database | 2 | CARBAPENEM, UNKNOWN BETA-LACTAM | Aeromonas hydrophila subsp. hydrophila | - | - | AY261379.1 | AAP97133.1 |
| imiS | Card Database | 1 | - | Aeromonas veronii | - | - | Y10415.1 | CAA71441.1 |
| imiH | Card Database | 1 | - | Aeromonas hydrophila | - | - | AJ548797.1 | CAD69003.1 |
| CphA-12 | Reference Gene Catalog | 1 | CARBAPENEM | Aeromonas hydrophila | - | - | KP771880.1 | AKI85140.1 |
Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas spp.
Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas spp.
Genetic linkage of the penicillinase gene, amp, and blrAB, encoding the regulator of beta-lactamase expression in Aeromonas spp.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
The cphA gene from Aeromonas hydrophila was identified as encoding a carbapenem-hydrolyzing metallo-beta-lactamase, demonstrating molecular heterogeneity among class B metallo-beta-lactamases.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
Emerging carbapenem-resistant Aeromonas spp. infections in Cali, Colombia.
The study identifies cphA as a potential cause of carbapenem resistance in Aeromonas spp., suggesting intrinsic metallo-beta-lactamase activity rather than acquired carbapenemases.
Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.
The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.
Metallo-beta-lactamases in the Age of Multidrug Resistance: From Structure and Mechanism to Evolution, Dissemination, and Inhibitor Design.
This review discusses the role of metallo-beta-lactamases (MBLs) in multidrug resistance, focusing on their structure, mechanism, and contribution to resistance against β-lactam antibiotics. It highlights the importance of MBLs in the spread of resistance and the challenges they pose for inhibitor design.
The first detection of two Aeromonas strains in mice of the genus Apodemus.
The study identified two Aeromonas strains, A. encheleia M-2 and A. hydrophila M-30, which exhibited resistance to carbapenems and piperacillin-tazobactam due to the expression of the CphA carbapenemase. A. hydrophila M-30 also showed resistance to trimethoprim.
Genomic Characterization of Aeromonas veronii Provides Insights into Taxonomic Assignment and Reveals Widespread Virulence and Resistance Genes throughout the World.
The study identifies mcr-7 and cphA as resistance genes in Aeromonas veronii, highlighting the presence of colistin and beta-lactam resistance mechanisms.
Antimicrobial resistance in aeromonads and new therapies targeting quorum sensing.
The paper discusses the prevalence of antimicrobial resistance in Aeromonas species, highlighting the presence of various beta-lactamase genes such as blaTEM-24, blaIMP-19, blaVIM-4, blaKPC-2, blaNDM-1, blaVIM-2, blaOXA-48, blaIMP-13, blaGES-5, blaTEM-1, blaSHV-12, blaVEB-9, blaMOX, blaFOX, blaACC, and others. It also identifies genes like cphA, vat, mcr-3.41, mcr-7.1, sul, dfr, tetA, rsmA, and adeF associated with resistance to sulfonamides, trimethoprim, tetracycline, polymyxin, and other antibiotics. The study emphasizes the role of horizontal gene transfer and mobile genetic elements in the dissemination of these resistance genes.
Clinical Presentation, Antimicrobial Resistance, and Treatment Outcomes of Aeromonas Human Infections: A 14-Year Retrospective Study and Comparative Genomics of 2 Isolates From Fatal Cases.
The study identified multiple antimicrobial resistance (AMR) genes, including bla OXA, ampC, cphA, and mcr-3, in Aeromonas dhakensis isolates from fatal cases. These genes conferred resistance to carbapenems, piperacillin-tazobactam, and colistin.
Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.
Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.
Nucleotide and amino acid sequences of the metallo-beta-lactamase, ImiS, from Aeromonas veronii bv. sobria.
The Aeromonas hydrophila cphA gene: molecular heterogeneity among class B metallo-beta-lactamases.
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