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Browse Mutations cphAG84A

GenecphA

carbapenem-hydrolyzing metallo-beta-lactamase

Protein ChangeG84A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: decreased the stability or catalytic activity of the CphA enzyme
Resistance To: carbapenems
Organisms: E. coli
Papers: 1

Paper Information1

1

Deep Sequencing of Random Mutant Libraries Reveals the Active Site of the Narrow Specificity CphA Metallo-β-Lactamase is Fragile to Mutations.

Research Article

PMID 27616327 · 2016

Mutation Information

Protein Change: G84A
Organisms: E. coli
Confers Resistance To: carbapenems
Effect on Function: decreased the stability or catalytic activity of the CphA enzyme
Validation Method: site-directed mutagenesis and MIC determination
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
GitHub
Zenodo archive
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research