Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydropteroate synthase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| T53A | - | - | Mycobacterium leprae, Mycobacterium smegmatis | dapsone | Reslit | Supported |
| T53R | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| T53I | - | - | Mycobacterium leprae, Mycobacterium smegmatis | dapsone | Reslit | Supported |
| P55R | - | - | Mycobacterium leprae, Mycobacterium smegmatis | dapsone | Reslit | Supported |
| P55L | - | Mycobacterium leprae, Mycobacterium smegmatis | dapsone | Reslit | Supported | |
| D91H | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| R94W | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| T88P | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| V48I | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| V48L | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| V48F | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| V48D | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| V48A | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| V48G | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| T53S | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| T53P | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| T53N | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| R54R | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| R54G | - | - | Mycobacterium smegmatis, Mycobacterium leprae | dapsone | Reslit | Candidate |
| R54W | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| P55T | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| P55A | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| P55S | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| P55H | - | - | Mycobacterium smegmatis | dapsone | Reslit | Candidate |
| T53V | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| T55I | - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
| V39I | - | slightly reduced binding affinity | Mycobacterium leprae | dapsone | Reslit | Candidate |
| - | - | Mycobacterium leprae | dapsone | Reslit | Candidate |
Primary multidrug-resistant leprosy, United States.
Research Article
Classic and new candidate markers for drug resistance in a large cohort of leprosy patients from the Amazon state, Brazil.
Research Article
Previously reported as a dapsone resistance mutation
Leprosy Drug Resistance Surveillance in Colombia: The Experience of a Sentinel Country.
Research Article
requires in vivo validation
Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance.
Research Article
Detection of antibiotic resistance in leprosy using GenoType LepraeDR, a novel ready-to-use molecular test.
Research Article
Nested PCR and the TaqMan SNP Genotyping Assay enhanced the sensitivity of drug resistance testing of Mycobacterium leprae using clinical specimens of leprosy patients.
Research Article
Dapsone Resistance in Leprosy Patients Originally from American Samoa, United States, 2010-2012.
Research Article
Mutations in the drug resistance-determining region of the folP1 gene are associated with dapsone resistance.
A new Mycobacterium leprae dihydropteroate synthase variant (V39I) from Papua, Indonesia.
Research Article
Molecular Surveillance of Antimicrobial Resistance of Mycobacterium leprae from Leprosy Patients in Zhejiang Province, China.
Research Article
Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types.
Research Article
Detected in clinical strains