grlA
Overview
- Papers
- 8
- Mutations
- 6
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| S80F | - | reduced the potency of ciprofloxacin | Staphylococcus aureus | levofloxacinquinolonesfluoroquinolones+2 more | Reslit | Supported |
| D84N | - | - | Staphylococcus pseudintermedius | enrofloxacin | Reslit | Candidate |
| S80I | - | - | Staphylococcus pseudintermedius | enrofloxacin | Reslit | Candidate |
| V82L | - | - | Staphylococcus aureus | levofloxacin | Reslit | Candidate |
| S80L | - | Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus epidermidis | ciprofloxacin | Reslit | Candidate | |
| S84L | - | Staphylococcus hominis, Staphylococcus simulans, Staphylococcus haemolyticus, Staphylococcus epidermidis | ciprofloxacin | Reslit | Candidate |
Impact of recA on levofloxacin exposure-related resistance development.
A point mutation (S80F) was encoded in grlA, despite exhibiting a susceptible phenotype.
Mutation Information
- Protein Change
- S80F, V82L
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- levofloxacin
- Source Database
- Reslit
Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- quinolones
- Source Database
- Reslit
Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- ciprofloxacin
- Source Database
- Reslit
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
Mutations promoted from gene entry 'grlA' (model emitted mutations_found inside genes).
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- quinolones
- Effect on Function
- reduced the potency of ciprofloxacin
- Source Database
- Reslit
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
Mutation Information
- Protein Change
- D84N, S80I
- Organisms
- Staphylococcus pseudintermedius
- Confers Resistance To
- enrofloxacin
- Source Database
- Reslit
Skin lesion caused by ST398 and ST1 MRSA, Spain.
Mutation Information
- Protein Change
- S80F
- Organisms
- Staphylococcus aureus
- Confers Resistance To
- ciprofloxacin|levofloxacin
- Source Database
- Reslit
Topoisomerase sequences of coagulase-negative staphylococcal isolates resistant to ciprofloxacin or trovafloxacin.
Mutations in grlA codons 80 and 84 associated with ciprofloxacin resistance.
Mutation Information
- Protein Change
- S80L, S84L
- Nucleotide Change
- TCT->CTT
- Organisms
- Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus simulans, Staphylococcus epidermidis
- Confers Resistance To
- ciprofloxacin
- Source Database
- Reslit