Browse AMR Genes

Explore antimicrobial resistance genes from the literature

mdtC

multidrug efflux transporter

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to mdtC

Browse AMR rules for mdtC

Validation StatusConfirmed2+ DBs

Overview

Mechanism: efflux
Validation Method: TBLASTN and MIC testing
Drug Classes: Tetracycline, Aminocoumarin, Penicillin, Cephalosporin, Carbapenem, Aminoglycoside, Fluoroquinolone, Diaminopyrimidines, Macrolide, Cloxacillin, Delafloxacin|Ciprofloxacin
Organisms: Escherichia coli, Raoultella planticola, Pseudomonas spp., Delftia tsuruhatensis MR-6/3H, Escherichia coli str. K-12 substr. MG1655
Geographic Location: Northern California|USA, Norway|China, Russia, South Africa
Papers: 7
Databases: Card DatabaseReslit
Mutations: 21

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V652C	-	-	Escherichia coli	Cloxacillin	Reslit	Candidate
S657C	-	-	Escherichia coli	Cloxacillin	Reslit	Candidate
I650C	-	-	Escherichia coli	Cloxacillin	Reslit

Papers7

1

Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria.

PMID 31423298 · 2019

The study shows that colonization of the gut of breastfed infants by B. infantis EVC001 leads to a significant reduction in antibiotic resistance genes (ARGs) compared to controls. The ARGs identified were mainly associated with Escherichia, Clostridium, and Staphylococcus, and conferred resistance to beta-lactams, fluoroquinolones, and multiple drug classes.

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: multidrug efflux transporter
Source Database: Reslit
Mechanism: efflux
Confers Resistance To: Tetracycline
Organisms Tested In: • Escherichia coli
• Raoultella planticola
Geographic Location: Northern California|USA
Validation Method: TBLASTN and MIC testing
Sequence Accession: PRJNA390646|PRJNA472982

2

Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient

PMID 31787070 · 2023

The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: efflux pump component
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: metagenomic read cloud sequencing and assembly

3

Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.

PMID 33498315 · 2021

The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: efflux pump component
Source Database: Reslit
Mechanism: active efflux of antibiotics
Confers Resistance To: Aminocoumarin
Organisms Tested In: • Pseudomonas spp.
Geographic Location: Norway|China
Validation Method: whole-genome sequencing
Sequence Accession: PRJNA685056

4

Genomic analysis of multidrug-resistant Delftia tsuruhatensis isolated from raw bovine milk.

PMID 38239723 · 2023

The study identifies multiple efflux pump genes and a genus-specific OXA-926-like beta-lactamase in the multidrug-resistant Delftia tsuruhatensis strain MR-6/3H, contributing to resistance against various antibiotics.

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: efflux pump
Source Database: Reslit
Mechanism: efflux pump
Confers Resistance To: PenicillinCephalosporinCarbapenemAminoglycosideFluoroquinoloneDiaminopyrimidinesTetracyclineAminocoumarinMacrolide
Organisms Tested In: • Delftia tsuruhatensis MR-6/3H
Geographic Location: Russia
Validation Method: genomic analysis
Sequence Accession: PRJNA903655|JAPMID000000000

5

Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.

PMID 38459466 · 2024

The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Reslit
Mechanism: antibiotic efflux
Confers Resistance To: Aminocoumarin
Organisms Tested In: • Escherichia coli
Geographic Location: South Africa
Validation Method: RGI analysis
Sequence Accession: NCBI:CP083125

6

Gene Information

Gene Name: mdtC
Allele: mdtC
Encodes: resistance-nodulation-cell division (RND) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Escherichia coli str. K-12 substr. MG1655
Sequence Accession: U00096.1
Protein Accession: AAC75137.1
Notes: ARO:3000794