Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane protein
Overview
| induces opening of the MtrE channel |
| Escherichia coli, Neisseria gonorrhoeae |
Vancomycin |
Reslit |
| Candidate |
| K397E | - | - | Escherichia coli | Vancomycin | Reslit | Candidate |
| N198L | - | Escherichia coli | Vancomycin | Reslit | Candidate |
| K390C | - | - | Escherichia coli | Tetracycline|Vancomycin | Reslit | Candidate |
| K225C | - | Escherichia coli | TetracyclineTetracycline|Nafcillin | Reslit | Candidate |
| K390E | - | - | Escherichia coli | Nafcillin|TetracyclineTetracycline|Nafcillin | Reslit | Candidate |
| K225E | - | - | Escherichia coli | Nafcillin|TetracyclineTetracycline|Nafcillin | Reslit | Candidate |
| R239C | - | - | Escherichia coli | Tetracycline | Reslit | Candidate |
Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump.
The study identifies the MtrCDE efflux pump components and characterizes the E434K mutation in MtrE as critical for vancomycin resistance, demonstrating that energy-dependent proton translocation is required for pump function.
PARMAP: A Pan-Genome-Based Computational Framework for Predicting Antimicrobial Resistance and Identifying Resistance-Associated Genetic Alterations
PARMAP, a pan-genome-based computational framework, successfully predicts antimicrobial resistance in Neisseria gonorrhoeae, Mycobacterium tuberculosis, and Escherichia coli. It identifies both known and novel AMR-associated gene alleles, including mutations in genes like GYRA, GYRB, ACNB, and PDXJ, which are linked to ciprofloxacin resistance.
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