Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
30S ribosomal protein S10
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R104H | - | - | Staphylococcus aureus | tigecycline | Reslit | Candidate |
| V57M | reduced affinity of 30S ribosome for tetracycline, reduces the affinity between tetracycline and the 30S ribosomal target, Reduced affinity of 30S ribosome for tetracycline, disrupts binding of the antimicrobial to ribosome, 30S ribosomal protein S10 | Neisseria gonorrhoeae, Neisseria elongata, Neisseria cinerea, Neisseria subflava, Neisseria canis, N. elongata, Neisseria commensals, Neisseria meningitidis | tetracyclinedoxycyclinemacrolides+1 more | Reference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| Y58D | - | contributes to the resistance to the third-generation tetracycline, 30S ribosomal protein S10 | Staphylococcus aureus, Enterococcus faecium, Staphylococcus lugdunensis | tigecyclineeravacyclineomadacycline | Reference Gene CatalogReslit | Confirmed |
| V57I | 30S ribosomal protein S10 | Klebsiella pneumoniae, Escherichia coli, Spirochaeta spp., Acinetobacter baumannii | tigecyclinetetracyclineminocycline | Reference Gene CatalogReslit | Confirmed | |
| K57M | - | 30S ribosomal protein S10 | Staphylococcus aureus, Staphylococcus lugdunensis | tetracyclinetigecycline | Reference Gene CatalogReslit | Confirmed |
| V57L | altered ribosome structure near the tigecycline-binding site or interfering with the coordination of Mg 2+ ions, which resulted in reduced tigecycline binding to the 16S rRNA therefore reduced the tigecycline susceptibility, 30S ribosomal protein S10 | Neisseria gonorrhoeae, Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Stenotrophomonas maltophilia, Neisseria meningitidis | tetracyclinetigecyclineminocycline | Reference Gene CatalogResFinder DatabaseReslit | Confirmed | |
| V57K | - | causally associated with reduced susceptibility to tetracyclines | Escherichia coli, Spirochaeta spp., Other Treponema | tetracycline | Reslit | Candidate |
| V57D | - | 30S ribosomal protein S10 | Escherichia coli | tetracyclinetigecyclineminocycline | Reference Gene CatalogReslit | Confirmed |
| V57N | - | - | Escherichia coli | tetracyclinetigecyclineminocycline | Reslit | Candidate |
| V57R | - | - | Escherichia coli | tetracyclinetigecyclineminocycline | Reslit | Candidate |
| V57G | - | causally associated with reduced susceptibility to tetracyclines | Escherichia coli, Treponema porcinum, Treponema spp., Spirochaeta spp. | tetracyclinetigecyclineminocycline | Reslit | Candidate |
| V57A | - | - | Escherichia coli | tetracyclinetigecyclineminocycline | Reslit | Candidate |
| D60Y | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene CatalogReslit | Confirmed |
| G11S | - | - | - | doxycycline | Reslit | Candidate |
| R123K | - | - | Neisseria gonorrhoeae | tetracycline | Reslit | Candidate |
| R123Q | - | - | Neisseria gonorrhoeae | tetracycline | Reslit | Candidate |
| K57Q | - | 30S ribosomal protein S10 | Enterococcus faecalis, Staphylococcus lugdunensis | eravacyclinetigecycline | Reference Gene CatalogReslit | Confirmed |
| E121K | - | - | Mycoplasma bovis | tetracycline | Reslit | Candidate |
| V57Q | - | 30S ribosomal protein S10 | Neisseria gonorrhoeae, Neisseria meningitidis | tetracycline | Reference Gene CatalogResFinder Database | Confirmed |
| RATHK53Q | - | 30S ribosomal protein S10 | Enterococcus faecalis, Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| IRATH52del | - | 30S ribosomal protein S10 | Enterococcus faecium | daptomycin | Reference Gene Catalog | Established |
| AT54EA | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| ATH54ETR | - | 30S ribosomal protein S10 | Enterococcus faecium | daptomycin | Reference Gene Catalog | Established |
| HK56RN | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| K57E | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| K57R | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| KY57RD | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| Y58S | - | 30S ribosomal protein S10 | Enterococcus faecium | tigecycline | Reference Gene Catalog | Established |
| HKYK56del | - | 30S ribosomal protein S10 | Staphylococcus lugdunensis | tigecycline | Reference Gene Catalog | Established |
| KY57MF | - | 30S ribosomal protein S10 | Staphylococcus lugdunensis | tigecycline | Reference Gene Catalog | Established |
| - | - | Escherichia coli | tetracyclinetigecyclineminocycline | Reslit | Candidate | |
| T39R | - | - | tigecycline | Reslit | Candidate |
Comparative genomics of ST5 and ST30 methicillin-resistant Staphylococcus aureus sequential isolates recovered from paediatric patients with cystic fibrosis.
Research Article
mutation in isolates
The antimicrobial resistance landscape of Neisseria gonorrhoeae in New Zealand from November 2018 to March 2019 and the role of sexual orientation in transmission.
Research Article
Mutation in rpsJ contributes to resistance to tetracycline.
Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China.
Research Article
rpsJ
Re-visiting the potential impact of doxycycline post-exposure prophylaxis (doxy-PEP) on the selection of doxycycline resistance in Neisseria commensals.
Research Article
Revisiting the potential impact of doxycycline post-exposure prophylaxis on the selection of doxycycline resistance in Neisseria commensals.
Research Article
From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings.
Research Article
A novel approach to associate genes and mutations with drug resistance phenotypes by comparative analysis of fully sequenced bacterial strains
Research Article
Molecular epidemiology of drug-resistant Neisseria gonorrhoeae in Russia (Current Status, 2015).
Research Article
WGS to predict antibiotic MICs for Neisseria gonorrhoeae.
Research Article
Exploration of the Neisseria Resistome Reveals Resistance Mechanisms in Commensals That May Be Acquired by N. gonorrhoeae through Horizontal Gene Transfer.
Research Article
Genomic surveillance of Neisseria gonorrhoeae in the Philippines, 2013-2014.
Research Article
Effects of Ribosomal Protein S10 Flexible Loop Mutations on Tetracycline and Tigecycline Susceptibility of Escherichia coli.
Research Article
Mutations in the flexible loop of ribosomal protein S10 affect tetracycline and tigecycline susceptibility.
rpsJ
Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance.
Research Article
Relation between genetic markers of drug resistance and susceptibility profile of clinical Neisseria gonorrhoeae strains.
Research Article
Change of Hypermucoviscosity in the Development of Tigecycline Resistance in Hypervirulent Klebsiella pneumoniae Sequence Type 23 Strains.
Research Article
Amino acid alteration in RpsJ was identified only in SMC1207-200-IR.
Hydrogel Droplet Microarray for Genotyping Antimicrobial Resistance Determinants in Neisseria gonorrhoeae Isolates.
Research Article
Neisseria gonorrhoeae FC428 Subclone, Vietnam, 2019-2020.
Research Article
associated with tetracycline resistance
The tigecycline resistance mechanisms in Gram-negative bacilli.
Review
associated with tigecycline resistance
Putative mutations associated with tetracycline resistance detected in Treponema spp.: an analysis of 4,355 Spirochaetales genomes.
Research Article
Mutations in rpsJ are associated with tetracycline resistance in various bacterial species.
Genomic analysis of reduced susceptibility to tigecycline in Enterococcus faecium.
Research Article
mutation in the rpsJ gene associated with reduced tigecycline susceptibility
rpsJ
Summary and Trends of the Russian Gonococcal Antimicrobial Surveillance Programme, 2005 to 2016.
Research Article
Genotypic and Phenotypic Characterization of Antimicrobial Resistance in Neisseria gonorrhoeae: a Cross-Sectional Study of Isolates Recovered from Routine Urine Cultures in a High-Incidence Setting.
Research Article
Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics.
Research Article
Equations To Predict Antimicrobial MICs in Neisseria gonorrhoeae Using Molecular Antimicrobial Resistance Determinants.
Research Article
Antimicrobial resistance genetic factor identification from whole-genome sequence data using deep feature selection.
Research Article
Antimicrobial resistance and heterogeneity of Neisseria gonorrhoeae isolated from patients attending sexually transmitted infection clinics in Lusaka, Zambia.
Research Article
Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018.
Research Article
The isolate had the V57M mutation in rpsJ, reducing affinity of 30S ribosome for tetracycline.
Whole-Genome Sequencing of Russian Neisseria Gonorrhoeae Isolates Related to ST 1407 Genogroup.
Research Article
Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer.
Research Article
Mutation in rpsJ leads to resistance to tetracycline.
A genomic perspective on the near-term impact of doxycycline post-exposure prophylaxis on Neisseria gonorrhoeae antimicrobial resistance.
Research Article
In vivo adaptive antimicrobial resistance in Klebsiella pneumoniae during antibiotic therapy.
Review
Whole genome analysis and antimicrobial resistance of Neisseria gonorrhoeae isolates from Ghana.
Research Article
Point mutation V57M in rpsJ was associated with high-level tetracycline resistance.
Two cases of extensively drug-resistant (XDR) Neisseria gonorrhoeae infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023.
Research Article
Antimicrobial susceptibility profile of Neisseria gonorrhoeae from patients attending a medical laboratory, Institut Pasteur de Madagascar between 2014 and 2020: phenotypical and genomic characterisation in a subset of Neisseria gonorrhoeae isolates.
Research Article
Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future.
Review
Mutations in rpsJ lead to resistance to tetracycline.
Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.
Research Article
Phylogeny and antimicrobial resistance in Neisseria gonorrhoeae isolates from Rio de Janeiro, Brazil.
Research Article
Rapid Emergence of a Pandrug-Resistant Klebsiella pneumoniae ST11 Isolate in an Inpatient in a Teaching Hospital in China After Treatment with Multiple Broad-Spectrum Antibiotics.
Research Article
may contribute to tigecycline resistance
Mechanism of Eravacycline Resistance in Clinical Enterococcus faecalis Isolates From China.
Research Article
Mutation in ribosomal protein S10 was found in Erava-induced resistant E. faecalis isolates.
Identification of Antimicrobial Resistance-Associated Genes through Whole Genome Sequencing of Mycoplasma bovis Isolates with Different Antimicrobial Resistances.
Research Article
The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
Research Article
carried V57M mutation leading to tetracycline resistance
High-level chromosomally mediated tetracycline resistance in Neisseria gonorrhoeae results from a point mutation in the rpsJ gene encoding ribosomal protein S10 in combination with the mtrR and penB resistance determinants.
Research Article
rpsJ
The ribosomal S10 protein is a general target for decreased tigecycline susceptibility.
Research Article
rpsJ
Anatomy of the posterior cruciate ligament. A review.
Review
rpsJ
Acinetobacter baumannii Repeatedly Evolves a Hypermutator Phenotype in Response to Tigecycline That Effectively Surveys Evolutionary Trajectories to Resistance.
Research Article
rpsJ
Rampant Parasexuality Evolves in a Hospital Pathogen during Antibiotic Selection.
Research Article
rpsJ
Focal epithelial hyperplasia (Heck's disease) in a Sudanese girl: case report.
Research Article
rpsJ
Deletions in a ribosomal protein-coding gene are associated with tigecycline resistance in Enterococcus faecium.
Research Article
rpsJ
In vitro activity of eravacycline and mechanisms of resistance in enterococci.
Research Article
rpsJ
[50th anniversary of the 1st All-Ukraine Congress of Obstetricians and Gynecologists].
Research Article
rpsJ
Gastrointestinal endoscopy outside teaching hospitals.
Research Article
rpsJ
Monoclonal antibodies against type II rat brain protein kinase C.
Research Article
rpsJ
Genomics of KPC-producing Klebsiella pneumoniae sequence type 512 clone highlights the role of RamR and ribosomal S10 protein mutations in conferring tigecycline resistance.
Research Article
rpsJ
Coincident gene conversion events in yeast that involve a large insertion.
Research Article
rpsJ
Mutations at the Ribosomal S10 Gene in Clinical Strains of Staphylococcus aureus with Reduced Susceptibility to Tigecycline.
Research Article
rpsJ
Genetic changes associated with tigecycline resistance in Staphylococcus aureus in vitro-selected mutants belonging to different lineages.
Research Article
rpsJ
First description of rpsJ and mepA mutations associated with tigecycline resistance in Staphylococcus aureus isolated from a cystic fibrosis patient during antibiotic therapy.
Research Article
rpsJ
Divalent azido-ATP analog for photoaffinity cross-linking of F1 subunits.
Research Article
rpsJ
Emergence of Tigecycline-Nonsusceptible Carbapenem-Resistant Klebsiella pneumoniae with Metallo-β-Lactamase and Transferable Ceftazidime-Avibactam Resistance in China.
Research Article
mutation reduces tigecycline susceptibility
Characterization of Extremely Drug-Resistant and Hypervirulent Acinetobacter baumannii AB030.
Research Article
Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
Research Article