ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeY58D

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: contributes to the resistance to the third-generation tetracycline, 30S ribosomal protein S10
Resistance To: tigecycline, eravacycline, omadacycline
Organisms: Staphylococcus aureus, Enterococcus faecium, Staphylococcus lugdunensis
Papers: 3

Paper Information3

Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China.

Research Article

PMID 37287125 · 2023

rpsJ

Mutation Information

rpsJ: p.Y58D

Protein Change: Y58D
Organisms: Staphylococcus aureus, Staphylococcus lugdunensis
Confers Resistance To: tigecyclineeravacyclineomadacycline
Effect on Function: contributes to the resistance to the third-generation tetracycline; 30S ribosomal protein S10
Validation Method: cloning experiments and MIC testing
Source Database: ReslitReference Gene Catalog

The ribosomal S10 protein is a general target for decreased tigecycline susceptibility.

Research Article

PMID 26124155 · 2015

rpsJ

Mutation Information

rpsJ: p.Y58D

Protein Change: Y58D
Organisms: Enterococcus faecium
Confers Resistance To: tigecycline
Effect on Function: 30S ribosomal protein S10
Source Database: Reference Gene Catalog

Gastrointestinal endoscopy outside teaching hospitals.

Research Article

PMID 4033484 · 1985

rpsJ

Mutation Information

rpsJ: p.Y58D

Protein Change: Y58D
Organisms: Enterococcus faecium
Confers Resistance To: tigecycline
Effect on Function: 30S ribosomal protein S10
Source Database: Reference Gene Catalog

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GenerpsJ

Protein ChangeY58D

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: contributes to the resistance to the third-generation tetracycline, 30S ribosomal protein S10
Resistance To: tigecycline, eravacycline, omadacycline
Organisms: Staphylococcus aureus, Enterococcus faecium, Staphylococcus lugdunensis
Papers: 3

Paper Information3

Exploring the third-generation tetracycline resistance of multidrug-resistant livestock-associated methicillin-resistant Staphylococcus aureus ST9 across healthcare settings in China.

Research Article

PMID 37287125 · 2023

rpsJ

Mutation Information

rpsJ: p.Y58D

Protein Change: Y58D
Organisms: Staphylococcus aureus, Staphylococcus lugdunensis
Confers Resistance To: tigecyclineeravacyclineomadacycline
Effect on Function: contributes to the resistance to the third-generation tetracycline; 30S ribosomal protein S10
Validation Method: cloning experiments and MIC testing
Source Database: ReslitReference Gene Catalog