Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
RND antibiotic efflux pump
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R603A | - | partial loss in the ability to confer triclosan resistance (2 to 4 fold MIC decrease in comparison to WT) and was matched by a partial loss of Nile Red efflux | Pseudomonas aeruginosa | Triclosan | Reslit | Candidate |
| Q181A | - | more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS | Pseudomonas aeruginosa | Triclosan | Reslit | Candidate |
| G598V | - | reduction of Nile Red efflux by TriABC and obliterated the TriABC-dependent resistance to SDS and triclosan |
| Pseudomonas aeruginosa |
Triclosan |
Reslit |
| Candidate |
| V698R | - | inactive in MIC measurements and Nile Red uptake assays | Pseudomonas aeruginosa | Triclosan | Reslit | Candidate |
| S276A | - | active in efflux of Nile Red and displayed resistance to triclosan but could only partially complement the SDS susceptibility of efflux-deficient Δ9 cells | Pseudomonas aeruginosa | Triclosan | Reslit | Candidate |
Unearthing Antibiotic Resistance Associated with Disturbance-Induced Permafrost Thaw in Interior Alaska.
The study identified various antibiotic resistance genes in Alaskan soil bacteria, highlighting the influence of phylogeny and disturbance on the resistome. Key genes included adeF, AbaQ, FosB, BcII, bcrC, TriC, KpnF, and BES-1, which conferred resistance to multidrug, quinolones, penicillins, cephalosporins, peptide antibiotics, triclosan, and broad-spectrum antibiotics.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
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