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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations triCQ181A

GenetriC

resistance-nodulation-cell division (RND) transporter

Protein ChangeQ181A

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS
Resistance To: Triclosan
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

1

A "Drug Sweeping" State of the TriABC Triclosan Efflux Pump from Pseudomonas aeruginosa.

PMID 32966762 · 2021

Mutations in the switch loop and substrate binding sites affect efflux activity.

Mutation Information

Protein Change: Q181A
Organisms: Pseudomonas aeruginosa
Confers Resistance To: Triclosan

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

more than 8-fold decrease in the MIC (minimal inhibitory concentration) of triclosan, a decrease in the ability to expel Nile Red, and a concurrent the loss of protection against SDS

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research