ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT253M

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: gain-of-function, two-component system sensor histidine kinase PmrB
Resistance To: colistin
Organisms: Pseudomonas aeruginosa
Papers: 2

Paper Information2

PmrB mutations promote polymyxin resistance of Pseudomonas aeruginosa isolated from colistin-treated cystic fibrosis patients.

Research Article

Multiple pmrB mutations were identified in clinical isolates, including single and double missense mutations in the periplasmic and DHP domains.

pmrB

Protein Change: T253M
Organisms: Pseudomonas aeruginosa
Confers Resistance To: colistin
Effect on Function: gain-of-function; two-component system sensor histidine kinase PmrB
Validation Method: episomal expression and MIC testing
Source Database: ReslitReference Gene Catalog

Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.

Research Article

missense mutation

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