Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Emergence and molecular characterization of extensively drug-resistant Mycobacterium tuberculosis clinical isolates from the Delhi Region in India.
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Previously reported
GenoType MTBDRsl for molecular detection of second-line-drug and ethambutol resistance in Mycobacterium tuberculosis strains and clinical samples.
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Mutations in rrs were associated with resistance to kanamycin and capreomycin.
Evaluation of MTBDRplus and MTBDRsl in Detecting Drug-Resistant Tuberculosis in a Chinese Population.
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Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing.
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Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.
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Globally diverse Mycobacterium tuberculosis resistance acquisition: a retrospective geographical and temporal analysis of whole genome sequences.
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Anti-tuberculosis drug resistance in Slovakia, 2018-2019: The first whole-genome epidemiological study.
Review
Whole-genome sequencing of Mycobacterium tuberculosis for prediction of drug resistance.
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Mutations in rrs were associated with resistance to amikacin, capreomycin, and streptomycin.
Transmission of multidrug-resistant tuberculosis in Jiangxi, China, and associated risk factors.
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Potential of nanopore sequencing for tuberculosis diagnosis and drug resistance detection.
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Outbreak Caused by Multidrug-Resistant Mycobacterium Tuberculosis with Unusual Combination of Resistance Mutations, Northern Argentina, 2006-2022.
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associated with resistance
Whole-genome sequencing and machine learning reveal key drivers of delayed sputum conversion in rifampicin-resistant tuberculosis.
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Key resistance-associated mutations in multidrug-resistant tuberculosis: a genomic study from Shanghai, China, with a focus on aminoglycosides.
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Sequence analyses of just four genes to detect extensively drug-resistant Mycobacterium tuberculosis strains in multidrug-resistant tuberculosis patients undergoing treatment.
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High level of cross-resistance between kanamycin, amikacin, and capreomycin among Mycobacterium tuberculosis isolates from Georgia and a close relation with mutations in the rrs gene.
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Mutations in the rrs gene are associated with resistance to kanamycin, amikacin, and capreomycin.
Comparative study on genotypic and phenotypic second-line drug resistance testing of Mycobacterium tuberculosis complex isolates.
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detected in 5 strains
Rapid diagnosis of extensively drug-resistant tuberculosis by use of a reverse line blot hybridization assay.
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Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa.
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Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing.
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First Insight Into the Fluoroquinolone and Aminoglycoside Resistance of Multidrug-Resistant Mycobacterium tuberculosis in Saudi Arabia.
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Whole genome analysis of extensively drug resistant Mycobacterium tuberculosis strains in Peru.
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Genomic Profiling of Mycobacterium tuberculosis Strains, Myanmar.
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Whole Genome Sequencing of Drug Resistant and Drug Susceptible Mycobacterium tuberculosis Isolates From Tigray Region, Ethiopia.
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associated with aminoglycoside resistance
Application of Amplicon-Based Targeted NGS Technology for Diagnosis of Drug-Resistant Tuberculosis Using FFPE Specimens.
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high-confidence mutation
Molecular Epidemiology and Polymorphism Analysis in Drug-Resistant Genes in M. tuberculosis Clinical Isolates from Western and Northern India.
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Mycobacterium tuberculosis Lineages Associated with Mutations and Drug Resistance in Isolates from India.
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Whole-genome sequencing reveals transmission pattern and drug resistance of Mycobacterium tuberculosis intra- or inter-hosts.
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Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.
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Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).
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Molecular detection of mutations associated with first- and second-line drug resistance compared with conventional drug susceptibility testing of Mycobacterium tuberculosis.
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mutations in rrs are associated with resistance to kanamycin and capreomycin
Mycobacterium tuberculosis population structure determines the outcome of genetics-based second-line drug resistance testing.
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Triplex real-time PCR melting curve analysis for detecting Mycobacterium tuberculosis mutations associated with resistance to second-line drugs in a single reaction.
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Mycobacterium tuberculosis resistance prediction and lineage classification from genome sequencing: comparison of automated analysis tools.
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This mutation was identified in strains resistant to streptomycin.
Prevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of China.
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Whole-genome sequence analysis and comparisons between drug-resistance mutations and minimum inhibitory concentrations of Mycobacterium tuberculosis isolates causing M/XDR-TB.
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rrs mutations are associated with resistance to kanamycin and amikacin
Putative extensive and pre-extensive drug resistant-tuberculosis associated with unusual genotypes on the Thailand-Myanmar border.
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Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis.
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Characterization of extensively drug-resistant Mycobacterium tuberculosis isolates circulating in Siberia.
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associated with high-level resistance to aminoglycosides and capreomycin
Genotypic susceptibility testing of Mycobacterium tuberculosis isolates for amikacin and kanamycin resistance by use of a rapid sloppy molecular beacon-based assay identifies more cases of low-level drug resistance than phenotypic Lowenstein-Jensen testing.
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associated with high-level resistance
Disparities in capreomycin resistance levels associated with the rrs A1401G mutation in clinical isolates of Mycobacterium tuberculosis.
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mutation in 16S rRNA gene
Added value of whole-genome sequencing for management of highly drug-resistant TB.
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Strong evidence for a causal association with a drug-resistant phenotype
GWAMAR: genome-wide assessment of mutations associated with drug resistance in bacteria.
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Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.
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Whole genome sequencing based characterization of extensively drug-resistant Mycobacterium tuberculosis isolates from Pakistan.
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Mutations in the rrs gene associated with aminoglycoside resistance
Primary Capreomycin Resistance Is Common and Associated With Early Mortality in Patients With Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal, South Africa.
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All capreomycin resistant isolates characterized in this cohort had the same A1401G mutation in rrs gene.
High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis.
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Mutations promoted from gene entry 'rrs' (model emitted mutations_found inside genes).
Diagnostic Performance of the New Version (v2.0) of GenoType MTBDRsl Assay for Detection of Resistance to Fluoroquinolones and Second-Line Injectables Drugs: a Multicenter Study.
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mutations in the rrs gene are associated with resistance to SLID
Acquisition of second-line drug resistance and extensive drug resistance during recent transmission of Mycobacterium tuberculosis in rural China.
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Drug resistance characteristics and cluster analysis of M. tuberculosis in Chinese patients with multiple episodes of anti-tuberculosis treatment.
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Correlating rrs and eis promoter mutations in clinical isolates of Mycobacterium tuberculosis with phenotypic susceptibility levels to the second-line injectables.
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Mycobacterium tuberculosis whole genome sequencing provides insights into the Manila strain and drug-resistance mutations in the Philippines.
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Confirmed in the study
Development and evaluation of novel bio-safe filter paper-based kits for sputum microscopy and transport to directly detect Mycobacterium tuberculosis and associated drug resistance.
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Mutation and Transmission Profiles of Second-Line Drug Resistance in Clinical Isolates of Drug-Resistant Mycobacterium tuberculosis From Hebei Province, China.
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Mutations in rrs are strongly associated with resistance to second-line injectable drugs
Pre-detection history of extensively drug-resistant tuberculosis in KwaZulu-Natal, South Africa.
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Genomic Analysis of Mycobacterium tuberculosis Isolates and Construction of a Beijing Lineage Reference Genome.
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Mutation in rrs is associated with aminoglycoside resistance.
Epidemiological cut-offs for Sensititre susceptibility testing of Mycobacterium tuberculosis: interpretive criteria cross validated with whole genome sequencing.
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Evaluation of MeltPro Assay in Identification of Second-Line Injectable Drug Resistance in Multidrug-Resistant Tuberculosis Isolates.
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mutations in rrs gene associated with resistance to kanamycin and amikacin
Predicting extensively drug-resistant Mycobacterium tuberculosis phenotypes with genetic mutations.
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Evaluation of the AID TB resistance line probe assay for rapid detection of genetic alterations associated with drug resistance in Mycobacterium tuberculosis strains.
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Performance of the MTBDRsl assay in Georgia.
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Pyrosequencing for rapid detection of tuberculosis resistance in clinical isolates and sputum samples from re-treatment pulmonary tuberculosis patients.
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MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.
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Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
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Mutation in rrs gene associated with high-level aminoglycoside resistance.
A rapid identification technique for drug-resistant Mycobacterium tuberculosis isolates using mismatch specific cleavage enzyme.
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Mutations in rrs are associated with aminoglycoside resistance.
Drug-Resistant Tuberculosis, Lebanon, 2016 - 2017.
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Confers resistance to amikacin, kanamycin, and streptomycin
Whole-Genome Sequencing of Drug-Resistant Mycobacterium tuberculosis Strains, Tunisia, 2012-2016.
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Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015.
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mutation leads to reduced binding of aminoglycosides, resulting in kanamycin resistance
Genetic Characterization of Second-Line Drug-Resistant and Extensively Drug-Resistant Mycobacterium tuberculosis from the Northern Region of India.
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Point mutation at position 1401 in the rrs gene is associated with aminoglycoside resistance
Transition bias influences the evolution of antibiotic resistance in Mycobacterium tuberculosis.
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mutation in rrs leading to streptomycin resistance
In silico evaluation of WHO-endorsed molecular methods to detect drug resistant tuberculosis.
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Mutations in rrs associated with aminoglycoside resistance
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
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mutations in rrs are associated with streptomycin resistance
Analysis of drug resistance among difficult-to-treat tuberculosis patients in Ghana identifies several pre-XDR TB cases.
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Whole-genome sequencing and transcriptome-characterized in vitro evolution of aminoglycoside resistance in Mycobacterium tuberculosis.
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Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin; CARD accession: CARD:3007536
Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin; CARD accession: CARD:3007537
Resistance Profiles to Second-Line Anti-Tuberculosis Drugs and Their Treatment Outcomes: A Three-Year Retrospective Analysis from South India.
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Drug resistance prediction for Mycobacterium tuberculosis with reference graphs.
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Molecular Analysis of Anti-Tuberculosis Drug Resistance of Mycobacterium tuberculosis Isolated in the Republic of Korea.
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Analysis of Drug-Resistance Characteristics and Genetic Diversity of Multidrug-Resistant Tuberculosis Based on Whole-Genome Sequencing on the Hainan Island, China.
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Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
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A precision overview of genomic resistance screening in Ecuadorian isolates of Mycobacterium tuberculosis using web-based bioinformatics tools.
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Transmission of fluoroquinolones resistance among multidrug-resistant tuberculosis in Shanghai, China: a retrospective population-based genomic epidemiology study.
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The rrs 1401A > G mutation was more frequent in FQ-R strains.
Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.
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Mutations in rrs are associated with resistance to aminoglycosides.
Evaluation of genetic mutations associated with Mycobacterium tuberculosis resistance to amikacin, kanamycin and capreomycin: a systematic review.
Review
Mutations in the rrs gene are associated with resistance to amikacin, kanamycin, and capreomycin.
Predictive value of molecular drug resistance testing of Mycobacterium tuberculosis isolates in Valle del Cauca, Colombia.
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Detection of second-line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays.
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Primary multidrug-resistant Mycobacterium tuberculosis in 2 regions, Eastern Siberia, Russian Federation.
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For all 3 mutations of eis associated with kanamycin resistance, rrs was wild type.
Comparison of line probe assay to BACTEC MGIT 960 system for susceptibility testing of first and second-line anti-tuberculosis drugs in a referral laboratory in South Africa.
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Multi-clonal evolution of multi-drug-resistant/extensively drug-resistant Mycobacterium tuberculosis in a high-prevalence setting of Papua New Guinea for over three decades.
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Mutations promoted from gene entry 'rrs' (model emitted mutations_found inside genes).
Evolution of drug resistance in Mycobacterium tuberculosis: a review on the molecular determinants of resistance and implications for personalized care.
Review
Second-line anti-tuberculosis drug resistance testing in Ghana identifies the first extensively drug-resistant tuberculosis case.
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Genetic profiling of Mycobacterium tuberculosis revealed "modern" Beijing strains linked to MDR-TB from Southwestern Colombia.
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Characterisation of drug-resistant Mycobacterium tuberculosis mutations and transmission in Pakistan.
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Investigating resistance in clinical Mycobacterium tuberculosis complex isolates with genomic and phenotypic antimicrobial susceptibility testing: a multicentre observational study.
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Mutation associated with aminoglycoside resistance.
A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance phenotypes to 13 antibiotics.
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mutations in rrs are associated with aminoglycoside resistance
Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin; CARD accession: CARD:3003481
Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to kanamycin; CARD accession: CARD:3007537
Evaluation of whole-genome sequence to predict drug resistance of nine anti-tuberculosis drugs and characterize resistance genes in clinical rifampicin-resistant Mycobacterium tuberculosis isolates from Ningbo, China.
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Targeted next-generation sequencing of Mycobacterium tuberculosis from patient samples: lessons learned from high drug-resistant burden clinical settings in Bangladesh.
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Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
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Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
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Evaluation of genotype MTBDRsl assay to detect drug resistance associated with fluoroquinolones, aminoglycosides and ethambutol on clinical sediments.
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Tuberculosis drug resistance mutation database.
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Detection of streptomycin and quinolone resistance in Mycobacterium tuberculosis by a low-density DNA array.
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Mutations conferring aminoglycoside and spectinomycin resistance in Borrelia burgdorferi.
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Borreliella burgdorferi 16S rRNA mutation conferring resistance to gentamicin; CARD accession: CARD:3003504
Integrating standardized whole genome sequence analysis with a global Mycobacterium tuberculosis antibiotic resistance knowledgebase.
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Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin; CARD accession: CARD:3003481
Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin; CARD accession: CARD:3003436
Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin; CARD accession: CARD:3003480
Mycobacterium tuberculosis 16S rRNA (rrnS) mutation conferring resistance to amikacin; CARD accession: CARD:3007536
Mechanism of resistance to amikacin and kanamycin in Mycobacterium tuberculosis.
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Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin; CARD accession: CARD:3003481
Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to amikacin; CARD accession: CARD:3003481
Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin; CARD accession: CARD:3003436
Detection of kanamycin-resistant Mycobacterium tuberculosis by identifying mutations in the 16S rRNA gene.
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Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to kanamycin; CARD accession: CARD:3003436
Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance.
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Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to streptomycin; CARD accession: CARD:3003480
Molecular analysis of kanamycin and viomycin resistance in Mycobacterium smegmatis by use of the conjugation system.
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Mycobacterium tuberculosis 16S rRNA mutation conferring resistance to viomycin; CARD accession: CARD:3003437
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