ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneblaPDC

class C beta-lactamase PDC-155

Protein ChangeE219K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced cefiderocol hydrolysis
Resistance To: Cefiderocol
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Functional and structural analyses of amino acid sequence variation in PDC β-lactamase reveal different mechanistic pathways toward cefiderocol resistance in Pseudomonas aeruginosa.

PMID 40422084 · 2025

Both mutations are located in the PDC β-lactamase and contribute to cefiderocol resistance.

Mutation Information

blaPDC: p.E219K

Protein Change: E219K
Organisms: Pseudomonas aeruginosa
Confers Resistance To

Browse AMR Mutations

Mutation Information