Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Quinolone resistance in Staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates.
Research Article
Mutations promoted from gene entry 'grlA' (model emitted mutations_found inside genes).
Efficacies of moxifloxacin, ciprofloxacin, and vancomycin against experimental endocarditis due to methicillin-resistant Staphylococcus aureus expressing various degrees of ciprofloxacin resistance.
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Target preference of 15 quinolones against Staphylococcus aureus, based on antibacterial activities and target inhibition.
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Bactericidal activities of BMS-284756, a novel Des-F(6)-quinolone, against Staphylococcus aureus strains with topoisomerase mutations.
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Skin lesion caused by ST398 and ST1 MRSA, Spain.
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Impact of recA on levofloxacin exposure-related resistance development.
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A point mutation (S80F) was encoded in grlA, despite exhibiting a susceptible phenotype.
In vitro and in vivo profiles of ACH-702, an isothiazoloquinolone, against bacterial pathogens.
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Mutations in grlA (Ser80Phe, Ser80Tyr, Ser80Phe Glu84Lys) lead to fluoroquinolone resistance.
Phenotypic and genotypic evaluation of fluoroquinolone resistance in clinical isolates of Staphylococcus aureus in Tehran.
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Variety of Antimicrobial Resistances and Virulence Factors in Staphylococcus aureus Isolates from Meat Products Legally and Illegally Introduced to Germany.
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Genomic and Long-Term Transcriptomic Imprints Related to the Daptomycin Mechanism of Action Occurring in Daptomycin- and Methicillin-Resistant Staphylococcus aureus Under Daptomycin Exposure.
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Mutations in grlA gene leading to reduced susceptibility to fluoroquinolones
Clonal Lineages, Antimicrobial Resistance, and PVL Carriage of Staphylococcus aureus Associated to Skin and Soft-Tissue Infections from Ambulatory Patients in Portugal.
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Clade-specific adaptation and global spread of Staphylococcus aureus ST188 with emergence of a multidrug-resistant MRSA sublineage.
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Fluoroquinolone resistance mutation
Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.
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Induction of fibronectin-binding proteins and increased adhesion of quinolone-resistant Staphylococcus aureus by subinhibitory levels of ciprofloxacin.
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Dual targeting of DNA gyrase and topoisomerase IV: target interactions of garenoxacin (BMS-284756, T-3811ME), a new desfluoroquinolone.
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Efficacy of garenoxacin in treatment of experimental endocarditis due to Staphylococcus aureus or viridans group streptococci.
Research Article
Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus.
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Mutation in grlA confers resistance to levofloxacin.
Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus.
Research Article
Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
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Genome-Wide Association Studies for the Detection of Genetic Variants Associated With Daptomycin and Ceftaroline Resistance in Staphylococcus aureus.
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This mutation is associated with ceftaroline resistance in S. aureus.
associated with ceftaroline resistance
Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
Research Article
The circulation of methicillin-resistant Staphylococcus aureus between humans, horses and the environment at the equine clinic.
Research Article
In vitro activities of novel nonfluorinated quinolones PGE 9262932 and PGE 9509924 against clinical isolates of Staphylococcus aureus and Streptococcus pneumoniae with defined mutations in DNA gyrase and topoisomerase IV.
Research Article
Mutations in grlA are associated with quinolone resistance.
Use of a three-dimensional microarray system for detection of levofloxacin resistance and the mecA gene in Staphylococcus aureus.
Research Article
Activity of gatifloxacin in an in vitro pharmacokinetic-pharmacodynamic model against Staphylococcus aureus strains either susceptible to ciprofloxacin or exhibiting various levels and mechanisms of ciprofloxacin resistance.
Research Article
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic.
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Virulence Determinants in Staphylococcus aureus Clones Causing Osteomyelitis in Italy.
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Dissecting the genetic features and evolution of Staphylococcus aureus sequence type 88: a global perspective.
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Present in most quinolone-resistant ST88 strains.
Single-molecule sequencing reveals the molecular basis of multidrug-resistance in ST772 methicillin-resistant Staphylococcus aureus.
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Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
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A Comparative Phenotypic and Genomic Analysis of Methicillin-Resistant Staphylococcus aureus ST45 Isolates From Cellulitis and Osteomyelitis in Taiwan.
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Detected only in OM-MRSA strains
Phylogenomics of Staphylococcus aureus CC5: Evolution, Resistance, and Virulence
Research Article
associated with fluoroquinolone resistance
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
Review
Mutations in grlA contribute to fluoroquinolone resistance.
Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health.
Review
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor.
Research Article
Intra-host variation of genetic lineages or AMR genotypes of CoPS
Research Article
Mutation in DNA gyrase subunit A leading to fluoroquinolone resistance
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
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Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.
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Antimicrobial resistance and clonality of Staphylococcus aureus causing bacteraemia in children admitted to the Manhiça District Hospital, Mozambique, over two decades.
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Genetic Determinants in MRSA Carriage and Their Association with Decolonization Outcome.
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Comparative genomics and drug resistance of a geographic variant of ST239 methicillin-resistant Staphylococcus aureus emerged in Russia.
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Mutation in grlA gene leads to levofloxacin resistance.
The Antimicrobial Activity of Ciprofloxacin-Loaded Niosomes against Ciprofloxacin-Resistant and Biofilm-Forming Staphylococcus aureus.
Research Article
Efflux pump activity potentiates the evolution of antibiotic resistance across S. aureus isolates.
Research Article
Outbreak of methicillin-resistant Staphylococcus aureus sequence type 1, spa type t1784, in an equine hospital in Japan.
Research Article
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
Review
Investigation of In Vitro Susceptibility and Resistance Mechanisms in Skin Pathogens: Perspectives for Fluoroquinolone Therapy in Canine Pyoderma.
Research Article
Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness
Research Article
Mutation in grlA contributes to ciprofloxacin resistance in some CoNS isolates.
Susceptibility and resistance genes to fluoroquinolones in methicillin-resistant Staphylococcus aureus isolated in 2002.
Research Article
Characterization of gyrA, gyrB, grlA and grlB mutations in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus.
Research Article
Epidemiology of the Staphylococcus aureus CA-MRSA USA300 in Belgium.
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Pharmacodynamic Modeling of Ciprofloxacin Resistance in Staphylococcus aureus.
Research Article
Evolution and Global Transmission of a Multidrug-Resistant, Community-Associated Methicillin-Resistant Staphylococcus aureus Lineage from the Indian Subcontinent.
Research Article
The grlA S80Y mutation was fixed in ST772-A2 and -A3.
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