ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeM145K

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disruption of pmrB leads to increased susceptibility to colistin
Resistance To: colistin
Organisms: Acinetobacter baumannii
Papers: 2

Paper Information2

Phosphoethanolamine Modification of Lipid A in Colistin-Resistant Variants of Acinetobacter baumannii Mediated by the pmrAB Two-Component Regulatory System.

Research Article

PMID 21576434 · 2011

Mutations in pmrB were found in colistin-resistant isolates.

Mutation Information

pmrB: p.M145K

Protein Change: M145K
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Effect on Function: disruption of pmrB leads to increased susceptibility to colistin
Validation Method: sequencing
Source Database: Reslit

Carbapenem-Resistant Acinetobacter baumannii in U.S. Hospitals: Diversification of Circulating Lineages and Antimicrobial Resistance.

Research Article

PMID 35311529 · 2022

Mutation Information

pmrB: p.M145K

Protein Change: M145K
Organisms: Acinetobacter baumannii
Confers Resistance To: colistin
Validation Method: sequencing and correlation with colistin resistance
Source Database: Reslit

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