ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneacrB

subunit of the AcrAB-TolC efflux pump

Protein ChangeV612F

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased resistance to tetracycline, fluoroquinolone, and linezolid, but reduced resistance to macrolides, increases resistance to linezolid, chloramphenicol, tetracycline, and fluoroquinolones, but decreases resistance to macrolides
Resistance To: Tetracycline|Fluoroquinolones, Linezolid|Chloramphenicol|Tetracycline|Fluoroquinolones
Organisms: Klebsiella pneumoniae, E. coli, Burkholderia pseudomallei
Papers: 1

Paper Information1

Conformational plasticity across phylogenetic clusters of RND multidrug efflux pumps and its impact on substrate specificity.

PMID 41298458 · 2025

The V612F mutation in AcrB leads to a conformational shift favoring the T state, affecting substrate binding and efflux.

Substitution of valine at position 612 with phenylalanine increases resistance to linezolid, chloramphenicol, tetracycline, and fluoroquinolones, but decreases resistance to macrolides.

Mutation Information

acrB: p.V612F

Protein Change: V612F
Organisms

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Mutation Information