ResLit - Antimicrobial Resistance Gene & Mutation Database

Acriflavin resistance protein B

Protein ChangeN282Y

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: impairs the efflux inhibitory action of NMP in a predominantly substrate-specific manner
Resistance To: linezolid
Organisms: Escherichia coli
Papers: 2

Paper Information2

Random mutagenesis of the multidrug transporter AcrB from Escherichia coli for identification of putative target residues of efflux pump inhibitors.

Research Article

Double mutation G141D N282Y

Comparative reassessment of AcrB efflux inhibitors reveals differential impact of specific pump mutations on the activity of potent compounds.

Research Article

Mutations in the AcrB efflux pump affect the activity of efflux pump inhibitors (EPIs).

Protein Change: N282Y
Organisms: Escherichia coli
Confers Resistance To: linezolid
Effect on Function: impairs the efflux inhibitory action of NMP in a predominantly substrate-specific manner
Validation Method: combinational susceptibility testing
Source Database: Reslit

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