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Browse Mutations hipAG22S

GenehipA

toxin-antitoxin module

Protein ChangeG22S

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased persister formation and antibiotic tolerance
Resistance To: ampicillin, cefotaxime
Organisms: E. coli
Papers: 1

Paper Information1

1

HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Research Article

PMID 26222023 · 2015

The G22S mutation in hipA leads to increased persister formation and antibiotic tolerance.

Mutation Information

Protein Change: G22S
Organisms: E. coli
Confers Resistance To: ampicillincefotaxime
Effect on Function: increased persister formation and antibiotic tolerance
Validation Method: whole genome sequencing and persister assays
Source Database: Reslit

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
Help
GitHub
Zenodo archive
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research