ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneacrB

Acriflavin resistance protein B

Protein ChangeG616N

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduces resistance
Resistance To: oxazolidinones, macrolides, erythromycin
Organisms: Escherichia coli
Papers: 2

Paper Information2

Efflux-Mediated Resistance to New Oxazolidinones and Pleuromutilin Derivatives in Escherichia coli with Class Specificities in the Resistance-Nodulation-Cell Division-Type Drug Transport Pathways.

Research Article

PMID 31209014 · 2019

Mutation Information

acrB: p.G616N

Protein Change: G616N
Organisms: Escherichia coli
Confers Resistance To: oxazolidinones
Validation Method: broth microdilution assays
Source Database: Reslit

Switch-loop flexibility affects transport of large drugs by the promiscuous AcrB multidrug efflux transporter.

Research Article

PMID 24914123 · 2014

The G616N substitution in the switch loop of AcrB reduces resistance to macrolides and other drugs.

Mutation Information

acrB: p.G616N

Protein Change: G616N
Organisms: Escherichia coli
Confers Resistance To: macrolideserythromycin
Effect on Function: reduces resistance
Validation Method: MIC assays, growth curve analysis, plate dilution tests, and dye accumulation assays
Source Database: Reslit

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