ResLit - Antimicrobial Resistance Gene & Mutation Database

penicillin-binding protein 2'

Protein ChangeK188A

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: cefoxitin, cefaclor, cephalexin, ampicillin, oxacillin, cephalothin, cefuroxime, cefotaxime
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

Penicillin-binding protein PBP2a provides variable levels of protection toward different β-lactams in Staphylococcus aureus RN4220.

Research Article

Both mutants failed to confer resistance, indicating the enzymatic activity of PBP2a is essential for resistance.

Protein Change: K188A
Nucleotide Change: A564G
Organisms: Staphylococcus aureus
Confers Resistance To: cefoxitincefaclorcephalexinampicillinoxacillincephalothincefuroximecefotaxime
Validation Method: mutant construct and MIC testing; site-directed mutagenesis and MIC assay
Source Database: Reslit

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