ResLit - Antimicrobial Resistance Gene & Mutation Database

Generrs

ribosomal RNA small subunit

Nucleotide ChangeC1192G

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogResFinder Database

Overview

Mechanism: Target modification, single resistance variant, 16S ribosomal RNA
Resistance To: spectinomycin
Organisms: Escherichia coli
Papers: 2

Paper Information2

Spectinomycin resistance at site 1192 in 16S ribosomal RNA of E. coli: an analysis of three mutants.

Research Article

PMID 2447957 · 1987

Mutation Information

rrs: c.C1192G

Nucleotide Change: C1192G
Organisms: Escherichia coli
Confers Resistance To: spectinomycin
Effect on Function: Target modification
Source Database: ResFinder Database

Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation.

Research Article

PMID 8127669 · 1994

Escherichia coli 16S rRNA (rrsB) mutation conferring resistance to spectinomycin; CARD accession: CARD:3003376

Mutation Information

rrs: c.C1192G

Nucleotide Change: C1192G
Organisms: Escherichia coli
Confers Resistance To: spectinomycin
Effect on Function: single resistance variant
Source Database: Card Database

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