Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Resistance to colistin associated with a single amino acid change in protein PmrB among Klebsiella pneumoniae isolates of worldwide origin.
Mutations promoted from gene entry 'pmrB' (model emitted mutations_found inside genes).
pmrB
A Molecular Perspective on Colistin and Klebsiella pneumoniae: Mode of Action, Resistance Genetics, and Phenotypic Susceptibility.
Mutations in PmrA/PmrB lead to constitutive activation of the arnBCADTEF operon and pmrC.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Three missense mutations identified, T157P validated to increase colistin MIC
Prevalence and molecular characteristics of colistin-resistant isolates among carbapenem-resistant Klebsiella pneumoniae in Central South China: a multicenter study.
Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China.
Prevalence and genetic characterization of clinically relevant extended-spectrum β-lactamase-producing Enterobacterales in the Gulf Cooperation Council countries.
Colistin Resistance Among Multiple Sequence Types of Klebsiella pneumoniae Is Associated With Diverse Resistance Mechanisms: A Report From India.
Molecular Analysis of Polymyxin Resistance among Carbapenemase-Producing Klebsiella pneumoniae in Colombia.
Mutations in pmrB
Resistance evolution of hypervirulent carbapenem-resistant Klebsiella pneumoniae ST11 during treatment with tigecycline and polymyxin.
Molecular Mechanisms of Colistin Resistance in Klebsiella pneumoniae in a Tertiary Care Teaching Hospital.
Emergence of colistin-resistant Klebsiella pneumoniae isolates in Iran: molecular mechanisms and resistance patterns
associated with colistin resistance
Analysis of colistin resistance in carbapenem-resistant Enterobacterales and XDR Klebsiella pneumoniae.
Clonal transmission and species-specific mechanisms of polymyxin resistance in carbapenem-resistant Enterobacteriaceae from Southwest China.
Mutations in pmrB contribute to polymyxin resistance.
In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.
Challenges in the Detection of Polymyxin Resistance: From Today to the Future.
Clinical and Microbiological Risk Factors for 30-Day Mortality of Bloodstream Infections Caused by OXA-48-Producing Klebsiella pneumoniae.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
Prevalence of Mutated Colistin-Resistant Klebsiella pneumoniae: A Systematic Review and Meta-Analysis.
Mutations in pmrB, particularly Thr157Pro, are frequently reported in colistin-resistant K. pneumoniae isolates and are associated with increased resistance.
Clonal transmission of polymyxin B-resistant hypervirulent Klebsiella pneumoniae isolates coharboring bla(NDM-1) and bla(KPC-2) in a tertiary hospital in China.
Molecular mechanisms of colistin- and multidrug-resistance in bacteria among patients with hospital-acquired infections.
mutations in pmrB gene contribute to colistin resistance
Heteroresistance to colistin in wild-type Klebsiella pneumoniae isolates from clinical origin.
Mutations in pmrB were associated with colistin resistance.
Resistome of carbapenem- and colistin-resistant Klebsiella pneumoniae clinical isolates.
point mutations in pmrB
Proteomic Investigation of the Signal Transduction Pathways Controlling Colistin Resistance in Klebsiella pneumoniae.
Mutations in PmrAB that constitutively activate arn operon transcription were found to cause colistin resistance.
High prevalence of mgrB-mediated colistin resistance among carbapenem-resistant Klebsiella pneumoniae is associated with biofilm formation, and can be overcome by colistin-EDTA combination therapy.
mutations in pmrB contribute to colistin resistance
Characterization of Carbapenemase-Producing Klebsiella pneumoniae Isolates from Two Romanian Hospitals Co-Presenting Resistance and Heteroresistance to Colistin.
Mutations in pmrB were observed in multiple strains and are associated with colistin resistance
High prevalence of polymyxin-heteroresistant carbapenem-resistant Klebsiella pneumoniae and its within-host evolution to resistance among critically ill scenarios.
Mutations in pmrB contribute to polymyxin resistance
Transport proteins. Export-import family expands.
pmrB
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