ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneompK36

outer membrane protein

Protein ChangeW125*

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: premature stop codon, outer membrane porin OmpK36
Resistance To: ertapenem, carbapenems
Organisms: Klebsiella pneumoniae
Papers: 2

Paper Information2

Predictability of Phenotype in Relation to Common β-Lactam Resistance Mechanisms in Escherichia coli and Klebsiella pneumoniae.

Research Article

PMID 26912748 · 2016

The paper states that mutations in ompK36 or absence of OmpK36 in all isolates in which reduced susceptibility to ertapenem (MIC, >1 mg/liter) was evident.

Mutation Information

ompK36: p.W125* / c.G374A

Protein Change: W125*
Nucleotide Change: G374A
Organisms: Klebsiella pneumoniae
Confers Resistance To: ertapenem
Effect on Function: premature stop codon
Validation Method: sequencing
Source Database: Reslit

Evolution of VIM-1-Producing Klebsiella pneumoniae Isolates from a Hospital Outbreak Reveals the Genetic Bases of the Loss of the Urease-Positive Identification Character.

Research Article

PMID 34060914 · 2021

ompK36

Mutation Information

ompK36: p.W125*

Protein Change: W125*
Organisms: Klebsiella pneumoniae
Confers Resistance To: carbapenems
Effect on Function: outer membrane porin OmpK36
Source Database: Reference Gene Catalog

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