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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations ampCR148W

GeneampC

beta-lactamase

Protein ChangeR148W

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased resistance to ceftazidime/avibactam and cefepime
Resistance To: Ceftazidime/avibactam|Cefepime
Organisms: Klebsiella aerogenes
Papers: 1

Paper Information1

1

In vivo emergence of resistance to ceftazidime/avibactam through modification of chromosomal AmpC β-lactamase in Klebsiella aerogenes.

PMID 39503481 · 2024

mutation in the chromosomal AmpC β-lactamase leading to resistance

Mutation Information

Protein Change: R148W
Organisms: Klebsiella aerogenes
Confers Resistance To: Ceftazidime/avibactam|Cefepime

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

increased resistance to ceftazidime/avibactam and cefepime

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research