Protein ChangeT446A
Validation StatusCandidate
Databases
Reslit
Overview
- Resistance To
- beta-lactam, penicillin
- Organisms
- Streptococcus mitis, Streptococcus pneumoniae
- Papers
- 2
Paper Information2
1
All detectable high-molecular-mass penicillin-binding proteins are modified in a high-level beta-lactam-resistant clinical isolate of Streptococcus mitis.
The resistant strain 127R shows T446A and A619G changes in the transpeptidase domain.
Mutation Information
- Protein Change
- T446A
- Organisms
- Streptococcus mitis
- Confers Resistance To
- beta-lactam
- Source Database
- Reslit
2
Highly variable penicillin resistance determinants PBP 2x, PBP 2b, and PBP 1a in isolates of two Streptococcus pneumoniae clonal groups, Poland 23F-16 and Poland 6B-20.
Mutation Information
- Protein Change
- T446A
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- penicillin
- Source Database
- Reslit
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