Browse AMR Mutations
Explore antimicrobial resistance mutations from the literature
Explore antimicrobial resistance mutations from the literature
Overview
Comparative in vitro activities of ciprofloxacin, clinafloxacin, gatifloxacin, levofloxacin, moxifloxacin, and trovafloxacin against Klebsiella pneumoniae, Klebsiella oxytoca, Enterobacter cloacae, and Enterobacter aerogenes clinical isolates with alterations in GyrA and ParC proteins.
mutations in parC are associated with fluoroquinolone resistance
parC
Susceptibility patterns of enteroaggregative Escherichia coli associated with traveller's diarrhoea: emergence of quinolone resistance.
Mutations in parC were linked to nalidixic acid resistance.
parC
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.
parC
Quinolone resistance among Escherichia coli strains from community-acquired urinary tract infections in Greece.
Additional mutation in parC associated with high-level resistance
parC
Emergence and spread of three clonally related virulent isolates of CTX-M-15-producing Escherichia coli with variable resistance to aminoglycosides and tetracycline in a French geriatric hospital.
Ciprofloxacin-resistant Salmonella enterica Typhimurium and Choleraesuis from pigs to humans, Taiwan.
Fluoroquinolone resistance in Salmonella enterica serotype Choleraesuis, Taiwan, 2000-2003.
An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients.
High-level ciprofloxacin resistance from point mutations in gyrA and parC confined to global hospital-adapted clonal lineage CC17 of Enterococcus faecium.
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.
Contribution of target gene mutations and efflux to decreased susceptibility of Salmonella enterica serovar typhimurium to fluoroquinolones and other antimicrobials.
Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.
Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Insights into the Environmental Resistance Gene Pool from the Genome Sequence of the Multidrug-Resistant Environmental Isolate Escherichia coli SMS-3-5
ParC mutations confer resistance to ciprofloxacin in combination with at least one mutation in gyrA.
Analysis of ciprofloxacin-resistant Salmonella strains from swine, chicken, and their carcasses in Taiwan and detection of parC resistance mutations by a mismatch amplification mutation assay PCR.
Emergence of quinolone resistance and cephalosporin MIC creep in Neisseria gonorrhoeae isolates from a cohort of young men in Kisumu, Kenya, 2002 to 2009.
Ciprofloxacin-resistant Salmonella enterica Serotype Typhi, United States, 1999-2008.
Ciprofloxacin-resistant Shigella sonnei among men who have sex with men, Canada, 2010.
Prominence of an O75 clonal group (clonal complex 14) among non-ST131 fluoroquinolone-resistant Escherichia coli causing extraintestinal infections in humans and dogs in Australia.
Quinolone resistance in absence of selective pressure: the experience of a very remote community in the Amazon forest.
Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.
associated with ciprofloxacin resistance
Abrupt emergence of a single dominant multidrug-resistant strain of Escherichia coli.
Chromosomal and plasmid-mediated fluoroquinolone resistance mechanisms among broad-spectrum-cephalosporin-resistant Escherichia coli isolates recovered from companion animals in the USA.
Ciprofloxacin-resistant Escherichia coli in Central Greece: mechanisms of resistance and molecular identification.
Characteristics of Quinolone Resistance in Escherichia coli Isolates from Humans, Animals, and the Environment in the Czech Republic.
Common mutations in quinolone-resistant isolates
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
Evaluation of Fluoroquinolone Resistance in Clinical Avian Pathogenic Escherichia coli Isolates from Flanders (Belgium).
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
Phylogenomic Investigation of Increasing Fluoroquinolone Resistance among Belgian Cases of Shigellosis between 2013 and 2018 Indicates Both Travel-Related Imports and Domestic Circulation.
Mutations in parC are associated with ciprofloxacin resistance.
Genetic but No Phenotypic Associations between Biocide Tolerance and Antibiotic Resistance in Escherichia coli from German Broiler Fattening Farms.
A global resource for genomic predictions of antimicrobial resistance and surveillance of Salmonella Typhi at pathogenwatch.
Distribution of fluoroquinolone resistance determinants in Carbapenem-resistant Klebsiella pneumoniae clinical isolates associated with bloodstream infections in China.
The Pheno- and Genotypic Characterization of Porcine Escherichia coli Isolates.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-Resistant Salmonella Enterica Serovar Kentucky ST 198 Strains Isolated from Human in Poland.
Emergence of novel strains of Shigella flexneri associated with sexual transmission in adult men in England, 2019-2020.
Genomic epidemiology of persistently circulating MDR Shigella sonnei strains associated with men who have sex with men (MSM) in Belgium (2013-19).
Integrating the Human and Animal Sides of Mycoplasmas Resistance to Antimicrobials.
Mutations in parC are associated with fluoroquinolone resistance.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
International High-Risk Clones Among Extended-Spectrum β-Lactamase-Producing Escherichia coli in Dhaka, Bangladesh.
Phylogenetic Analysis Reveals Distinct Evolutionary Trajectories of the Fluoroquinolones-Resistant Escherichia coli ST1193 From Fuzhou, China.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
Mutational Diversity in the Quinolone Resistance-Determining Regions of Type-II Topoisomerases of Salmonella Serovars.
Mutations in parC are common in quinolone-resistant Salmonella isolates.
ParC mutations are less common but contribute to ciprofloxacin resistance.
Whole-Genome Sequencing-Based Antimicrobial Resistance Characterization and Phylogenomic Investigation of 19 Multidrug-Resistant and Extended-Spectrum Beta-Lactamase-Positive Escherichia coli Strains Collected From Hospital Patients in Benin in 2019.
Acquired resistome and plasmid sequencing of mcr-1 carrying MDR Enterobacteriaceae from poultry and their relationship to STs associated with humans.
Diversity in the Characteristics of Klebsiella pneumoniae ST101 of Human, Environmental, and Animal Origin.
A Descriptive Analysis of Urinary ESBL-Producing-Escherichia coli in Cerdanya Hospital.
associated with ciprofloxacin resistance
Correlation between Phenotypic and In Silico Detection of Antimicrobial Resistance in Salmonella enterica in Canada Using Staramr.
Prevalence and molecular characteristics of carbapenem-resistant Escherichia coli isolated from dogs in South Korea.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
Molecular mechanisms impact on fluoroquinolone resistance among E.coli from enteric carriage monitoring before prostate biopsy and earliest description of qnrB81.
Mutations in the QRDR of parC contribute to fluoroquinolone resistance.
Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
One day in Denmark: whole-genome sequence-based analysis of Escherichia coli isolates from clinical settings.
Pandemic one health clones of Escherichia coli and Klebsiella pneumoniae producing CTX-M-14, CTX-M-27, CTX-M-55 and CTX-M-65 ESβLs among companion animals in northern Ecuador.
Comprehensive genomic insights into a highly pathogenic clone ST656 of mcr8.1 containing multidrug-resistant Klebsiella pneumoniae from Bangladesh.
In vitro selection of resistance in Escherichia coli and Klebsiella spp. at in vivo fluoroquinolone concentrations.
Quinolone resistance in Escherichia coli from Accra, Ghana.
A global atlas and drivers of antimicrobial resistance in Salmonella during 1900-2023.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
Strains with ParC T57S but not exhibiting resistance to NAL and CIP were determined as non-resistant to quinolones.
Antimicrobial Resistance Genotypes and Mobile Genetic Elements of Poultry-Derived Escherichia coli: A Retrospective Genomic Study from the United States.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
Mutation in parC contributes to fluoroquinolone resistance in various bacterial species.
Prevalence and genetic characteristics of antimicrobial-resistant Escherichia coli in wild birds in Japan.
Prevalence, antimicrobial susceptibility, and virulence profiles of fluoroquinolone-resistant Escherichia coli isolated from companion animals in Sapporo, Japan.
Genetic diversity and antimicrobial resistance profiles of Salmonella enterica in the broiler supply chain in Harare, Zimbabwe: tracking transmission from farm to table.
Resistance Mechanisms of Fluoroquinolone in Escherichia coli Isolated from Taihe Black-Boned Silky Fowl Exhibiting Abnormally Slow Fluoroquinolone Metabolism in Jiangxi, China.
The ParC-S80I mutation was reported as novel in this study.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
Mutation in the quinolone-resistance-determining region of the parC gene
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
Antimicrobial susceptibilities and plasmid contents of Neisseria gonorrhoeae isolates from commercial sex workers in Dhaka, Bangladesh: emergence of high-level resistance to ciprofloxacin.
Mutations in parC were associated with ciprofloxacin resistance.
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.
parC
Topoisomerase IV is a target of quinolones in Escherichia coli.
Mutations in parC contribute to quinolone resistance in E. coli.
Unknown phenotype if each mutation occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations
Sparfloxacin selects gyrase mutations in first-step Mycoplasma hominis mutants, whereas ofloxacin selects topoisomerase IV mutations.
Treatment failure in a typhoid patient infected with nalidixic acid resistant S. enterica serovar Typhi with reduced susceptibility to ciprofloxacin: a case report from Cameroon.
Mutation in parC was suggested as a possible cause of reduced susceptibility to ciprofloxacin.
Characterization of multiple-antimicrobial-resistant Escherichia coli isolates from diseased chickens and swine in China.
Ciprofloxacin-resistant Salmonella Kentucky in travelers.
Mutations in parC contribute to ciprofloxacin resistance.
Mutations in the quinolone resistance determining region in Staphylococcus epidermidis recovered from conjunctiva and their association with susceptibility to various fluoroquinolones.
Chronological study of antibiotic resistances and their relevant genes in Korean avian pathogenic Escherichia coli isolates.
Mechanisms of fluoroquinolone resistance in Escherichia coli isolates from food-producing animals.
Emergence of fluoroquinolone resistance in Salmonella enterica serovar Typhi in Andaman and Nicobar Islands, India.
Mutations in gyrA and parC were identified in fluoroquinolone-resistant S. Typhi strains.
Epidemiology and characteristics of Escherichia coli sequence type 131 (ST131) from long-term care facility residents colonized intestinally with fluoroquinolone-resistant Escherichia coli.
Plasmid-mediated quinolone resistance determinants in quinolone-resistant Escherichia coli isolated from patients with bacteremia in a university hospital in Taiwan, 2001-2015.
mutations in gyrA and parC were found in PMQR-harboring isolates
Multidrug-Resistant Shigella Infections in Patients with Diarrhea, Cambodia, 2014-2015.
Detected in S. sonnei isolate
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
Single amino acid polymorphism in parC codon 80 (Ser to Ile)
Molecular Epidemiology and Clinical Characterization of Carbapenemase-Producing Enterobacter Species From an International Cohort.
Prevalence of plasmid-mediated quinolone resistance in Escherichia coli isolated from diseased animals in Taiwan.
Treatment Response in Enteric Fever in an Era of Increasing Antimicrobial Resistance: An Individual Patient Data Analysis of 2092 Participants Enrolled into 4 Randomized, Controlled Trials in Nepal.
Mutation in DNA topoisomerase IV gene associated with increased MICs against fluoroquinolones.
Whole genome sequencing, molecular typing and in vivo virulence of OXA-48-producing Escherichia coli isolates including ST131 H30-Rx, H22 and H41 subclones.
Genomic epidemiology of emerging ESBL-producing Salmonella Kentucky bla (CTX-M-14b) in Europe.
Genomic Serotyping, Clinical Manifestations, and Antimicrobial Resistance of Nontyphoidal Salmonella Gastroenteritis in Hospitalized Children in Ho Chi Minh City, Vietnam.
associated with ciprofloxacin resistance
The Characteristic of Virulence, Biofilm and Antibiotic Resistance of Klebsiella pneumoniae.
Molecular Characterization of Extended-Spectrum β-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Among the Pediatric Population in Qatar.
Multiple Introductions of Salmonella enterica Serovar Typhi H58 with Reduced Fluoroquinolone Susceptibility into Chile.
Mutation in lineage II
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
Detection of gyrA and parC Mutations and Prevalence of Plasmid-Mediated Quinolone Resistance Genes in Klebsiella pneumoniae.
Whole-genome analyses of extended-spectrum or AmpC β-lactamase-producing Escherichia coli isolates from companion dogs in Japan.
associated with fluoroquinolone resistance
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in central Iran.
Mutation in parC at amino acid 80 (serine to isoleucine)
Clonal Clusters, Molecular Resistance Mechanisms and Virulence Factors of Gram-Negative Bacteria Isolated from Chronic Wounds in Ghana.
Prevalence and Characterization of Quinolone-Resistance Determinants in Escherichia coli Isolated from Food-Producing Animals and Animal-Derived Food in the Philippines.
Mutations in bdcA and valS Correlate with Quinolone Resistance in Wastewater Escherichia coli.
known mutation
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
Genome profiling of fluoroquinolone-resistant uropathogenic Escherichia coli isolates from Brazil.
Correlation between antibiotic resistance and phylogenetic types among multidrug-resistant Escherichia coli isolated from urinary tract infections.
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
Present in 2020 S. sonnei strain
Antimicrobial Resistance of Non-Typhoid Salmonella in Meat and Meat Products.
Antimicrobial Resistance and Molecular Epidemiology of Uropathogenic Escherichia coli Isolated From Female Patients in Shanghai, China.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
Genomic comparisons of Escherichia coli ST131 from Australia.
Dual gyrA-1AB and parC-1aAB mutations are unique to clade C ST131 isolates but were identified in some clade A isolates.
Ciprofloxacin-resistant Gram-negative isolates from a tertiary care hospital in Eastern India with novel gyrA and parC gene mutations.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
Population snapshot of the extended-spectrum β-lactamase-producing Escherichia coli invasive strains isolated from a Hungarian hospital.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
Mutation in parC leads to decreased susceptibility to fluoroquinolones.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
Mutations in parC contribute to fluoroquinolone resistance.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
Single amino acid exchange in ParC
Wild Boars as an Indicator of Environmental Spread of ESβL-Producing Escherichia coli.
Genetic and in-silico approaches for investigating the mechanisms of ciprofloxacin resistance in Salmonella typhi: Mutations, extrusion, and antimicrobial resistance.
Analysis of molecular mechanisms of delafloxacin resistance in Escherichia coli.
Mutations in QRDRs are associated with delafloxacin resistance
Genomic dynamics of high-risk carbapenem-resistant klebsiella pneumoniae clones carrying hypervirulence determinants in Egyptian clinical settings.
found in some isolates
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
Genomic Characterization and Antimicrobial Resistance of ESBL-Producing, Escherichia coli Isolates in Suzhou, China.
Ribosome Phenotypes Can Be Used to Classify Ciprofloxacin-Resistant Clinical E. coli Isolates
Mutations in parC lead to ciprofloxacin resistance
Non-typhoidal Salmonella transmission reservoirs in Sub-Saharan Africa: a genomic assessment from a one health perspective.
Nalidixic acid-a good marker of fluoroquinolone resistance mechanisms in Escherichia coli.
Mechanisms of fluoroquinolone resistance among Escherichia coli isolates from urinary tract infections in Thailand.
Genomic Analysis of Antibiotic Resistance and Virulence Profiles in Escherichia coli Linked to Sternal Bursitis in Chickens: A One Health Perspective.
Variants of β-lactamase-encoding genes are disseminated by multiple genetically distinct lineages of bloodstream Escherichia coli.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
Analysis of the microbial spectrum of urinary tract infections and antibiotic resistance of UPEC in Central Inner Mongolia, China.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
Type II topoisomerase quinolone resistance-determining regions of Aeromonas caviae, A. hydrophila, and A. sobria complexes and mutations associated with quinolone resistance.
Mutations at positions 80 and 84 in parC lead to quinolone resistance.
Salmonella enterica serotype Choleraesuis: epidemiology, pathogenesis, clinical disease, and treatment.
Mutations in parC contribute to fluoroquinolone resistance
Nalidixic acid-resistant Salmonella enterica serotype Typhi presenting as a primary psoas abscess: case report and review of the literature.
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Pseudomonas aeruginosa in dogs and cats.
Rapid determination of quinolone resistance in Acinetobacter spp.
Rapid assessment of the effect of ciprofloxacin on chromosomal DNA from Escherichia coli using an in situ DNA fragmentation assay.
Mutations in ParC associated with reduced ciprofloxacin sensitivity.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
Evaluation of Machine Learning and Rules-Based Approaches for Predicting Antimicrobial Resistance Profiles in Gram-negative Bacilli from Whole Genome Sequence Data.
Genetic characterization of fluoroquinolone-resistant Escherichia coli associated with bovine mastitis in India.
South Asia as a Reservoir for the Global Spread of Ciprofloxacin-Resistant Shigella sonnei: A Cross-Sectional Study.
Identification of an NDM-5-producing Escherichia coli Sequence Type 167 in a Neonatal Patient in China.
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015) : Jeddah, Kingdom of Saudi Arabia. 30 November - 3 December 2015.
Wild type parC genes were found in 4/18 phenotypic FQ resistant NTS isolates
Genetic and pathogenic difference between Streptococcus agalactiae serotype Ia fish and human isolates.
Mutations in gyrA and parC were observed in two levofloxacin and moxifloxacin resistant isolates.
Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coli.
Introduction and establishment of fluoroquinolone-resistant Shigella sonnei into Bhutan.
The ST131 Escherichia coli H22 subclone from human intestinal microbiota: Comparison of genomic and phenotypic traits with those of the globally successful H30 subclone.
Genomic Analysis of Multidrug-Resistant Escherichia coli from North Carolina Community Hospitals: Ongoing Circulation of CTX-M-Producing ST131-H30Rx and ST131-H30R1 Strains.
The effects of different enrofloxacin dosages on clinical efficacy and resistance development in chickens experimentally infected with Salmonella Typhimurium.
Profiling Virulence and Antimicrobial Resistance Markers of Enterovirulent Escherichia Coli from Fecal Isolates of Adult Patients with Enteric Infections in West Cameroon.
Phylogenetic and Evolutionary Analysis Reveals the Recent Dominance of Ciprofloxacin-Resistant Shigella sonnei and Local Persistence of S. flexneri Clones in India.
Mutation in par C contributes to fluoroquinolone resistance.
Epidemic characterization and molecular genotyping of Shigella flexneri isolated from calves with diarrhea in Northwest China.
Escherichia coli-associated granulomatous colitis in dogs treated according to antimicrobial susceptibility profiling.
The level of antimicrobial resistance of sewage isolates is higher than that of river isolates in different Escherichia coli lineages.
Trends in Population Dynamics of Escherichia coli Sequence Type 131, Calgary, Alberta, Canada, 2006-2016
Epidemic and molecular characterization of fluoroquinolone-resistant Shigella dysenteriae 1 isolates from calves with diarrhea.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
Mutation in parC contributes to fluoroquinolone resistance.
Novel Pharmacokinetic/Pharmacodynamic Parameters Quantify the Exposure-Effect Relationship of Levofloxacin against Fluoroquinolone-Resistant Escherichia coli.
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
Molecular characterization of fluoroquinolone-resistant Escherichia coli from broiler breeder farms.
Mutations in parC are associated with fluoroquinolone resistance.
Emergence of mcr-1-Harboring Salmonella enterica Serovar Sinstorf Type ST155 Isolated From Patients With Diarrhea in Jiangsu, China.
Mutations in parC contribute to ciprofloxacin resistance.
Genomic Analysis of Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 From Spanish Hospitals.
Common mutations in ciprofloxacin-resistant isolates
Optimizing Nanopore Sequencing for Rapid Detection of Microbial Species and Antimicrobial Resistance in Patients at Risk of Surgical Site Infections.
Detected in Salmonella enterica
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
Chromosomal quinolone resistance mutations in parC
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
Draft Genome Sequence of a Uropathogenic Escherichia coli Sequence Type 44 Strain Carrying Multiple Antimicrobial Resistance Genes.
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response.
Detection of Delafloxacin Resistance Mechanisms in Multidrug-Resistant Klebsiella pneumoniae.
Prevalence and characterization of ciprofloxacin-resistant Salmonella enterica spp. isolated from food animals during 2010-2023 in South Korea.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
Confers resistance to fluoroquinolones.
Whole genome sequencing reveals virulence-mobile element linkages and phylogenetic diversity in multidrug-resistant Escherichia coli from Nigeria.
Genomic analyses reveal presence of extensively drug-resistant Salmonella enterica serovars isolated from clinical samples in Guizhou province, China, 2019-2023.
Detected in S. Kentucky
Genomic insights into antimicrobial resistance and virulence of E. coli in central Ethiopia: a one health approach.
Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
Characteristics of quinolone resistance in Escherichia coli isolated from wildlife in Poland.
Mutations in QRDR region are associated with high MIC values
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
Mutations in ParC (S80I, T251A) responsible for fluoroquinolone resistance
Emergence and regional spread of extended-spectrum β-lactamase-producing Klebsiella pneumoniae ST307 at a Japanese tertiary-care hospital.
Combating Klebsiella pneumoniae: from antimicrobial resistance mechanisms to phage-based combination therapies.
Mutation in parC contributes to quinolone resistance.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
Mutations in parC contribute to fluoroquinolone resistance
Phenotypic and molecular characterization of extended-spectrum beta-lactamase-producing Escherichia coli in Bangladesh.
Trends in serotype distribution and antimicrobial susceptibility in Salmonella enterica isolates from humans in Belgium, 2009 to 2013.
The emergence of the 16S rRNA methyltransferase RmtB in a multidrug-resistant Serratia marcescens isolate in China.
Molecular epidemiology and genetic diversity of fluoroquinolone-resistant Escherichia coli isolates from patients with community-onset infections in 30 Chinese county hospitals.
Fluoroquinolone-resistant and extended-spectrum β-lactamase-producing Escherichia coli from the milk of cows with clinical mastitis in Southern Taiwan.
A high-resolution genomic analysis of multidrug-resistant hospital outbreaks of Klebsiella pneumoniae.
Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
Enhanced resistance to fluoroquinolones in laboratory-grown mutants & clinical isolates of Shigella due to synergism between efflux pump expression & mutations in quinolone resistance determining region.
Mutations in QRDR of parC contribute to fluoroquinolone resistance
Emergence and spread of O16-ST131 and O25b-ST131 clones among faecal CTX-M-producing Escherichia coli in healthy individuals in Hunan Province, China.
parC 1b
Drug resistance-associated mutations in Mycoplasma genitalium in female sex workers, Japan.
Antimicrobial susceptibility of travel-related Salmonella enterica serovar Typhi isolates detected in Switzerland (2002-2013) and molecular characterization of quinolone resistant isolates.
'Supermutators' found amongst highly levofloxacin-resistant E. coli isolates: a rapid protocol for the detection of mutation sites.
The parC-S80I mutation was strongly associated with I/R/HR isolates.
Outbreak of Ciprofloxacin-Resistant Shigella sonnei Associated with Travel to Vietnam, Republic of Korea.
Emergence of Ciprofloxacin-Resistant Salmonella enterica Serovar Typhi in Italy.
Fluoroquinolone Resistance Mechanisms and population structure of Enterobacter cloacae non-susceptible to Ertapenem in North-Eastern France.
mutations in QRDR
Stepwise evolution of pandrug-resistance in Klebsiella pneumoniae.
In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem.
Quinolone resistance and ornithine decarboxylation activity in lactose-negative Escherichia coli.
Quinolone resistance mutations in the faecal microbiota of Swedish travellers to India.
Alterations in the Quinolone Resistance-Determining Regions and Fluoroquinolone Resistance in Clinical Isolates and Laboratory-Derived Mutants of Mycoplasma bovis: Not All Genotypes May Be Equal.
Use of whole-genome sequencing to trace, control and characterize the regional expansion of extended-spectrum β-lactamase producing ST15 Klebsiella pneumoniae.
Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility.
Mutations in parC are associated with fluoroquinolone resistance.
Fluoroquinolone-Resistant Enteric Bacteria in Sub-Saharan Africa: Clones, Implications and Research Needs.
Mutations in QRDR of gyrA and parC contribute to fluoroquinolone resistance.
Antimicrobial Resistance Mechanisms
Antimicrobial resistance trends in blood culture positive Salmonella Paratyphi A isolates from Pondicherry, India.
Frequency, Antimicrobial Resistance and Genetic Diversity of Klebsiella pneumoniae in Food Samples.
Endemic fluoroquinolone-resistant Salmonellaenterica serovar Kentucky ST198 in northern India.
A systematic review of antimicrobial resistance of typhoidal Salmonella in India.
S. Enteritidis and S. Typhimurium Harboring SPI-1 and SPI-2 Are the Predominant Serotypes Associated With Human Salmonellosis in Saudi Arabia.
Plasmid-mediated fluoroquinolone resistance associated with extra-intestinal Escherichia coli isolates from hospital samples.
Analysis of isolates from Bangladesh highlights multiple ways to carry resistance genes in Salmonella Typhi.
Mutations in parC are associated with ciprofloxacin resistance.
Pandemic fluoroquinolone resistant Escherichia coli clone ST1193 emerged via simultaneous homologous recombinations in 11 gene loci.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
Informal genomic surveillance of regional distribution of Salmonella Typhi genotypes and antimicrobial resistance via returning travellers.
Mutations in the quinolone resistance determining region (QRDR) of gyrA and parC are associated with reduced susceptibility to fluoroquinolones.
Distinct impact of antibiotics on the gut microbiome and resistome: a longitudinal multicenter cohort study.
Detected in one patient (ID 512) under ciprofloxacin treatment.
An Outbreak of Carbapenem-Resistant and Hypervirulent Klebsiella pneumoniae in an Intensive Care Unit of a Major Teaching Hospital in Wenzhou, China.
Persistent circulation of a fluoroquinolone-resistant Salmonella enterica Typhi clone in the Indian subcontinent.
Mutations in gyrA and parC contribute to fluoroquinolone resistance.
Prevalence of Quinolone Resistance of Extended-Spectrum β-Lactamase-Producing Escherichia coli with ST131-fimH30 in a City Hospital in Hyogo, Japan.
Shedding of OXA-181 carbapenemase-producing Escherichia coli from companion animals after hospitalisation in Switzerland: an outbreak in 2018.
Genomic Characterization of Prevalent mcr-1, mcr-4, and mcr-5 Escherichia coli Within Swine Enteric Colibacillosis in Spain.
Etiology of childhood diarrhoea among under five children and molecular analysis of antibiotic resistance in isolated enteric bacterial pathogens from a tertiary care hospital, Eastern Odisha, India.
Pathogenomics and Evolutionary Epidemiology of Multi-Drug Resistant Clinical Klebsiella pneumoniae Isolated from Pretoria, South Africa.
Ciprofloxacin-Resistant Salmonella enterica Serovar Kentucky ST198 in Broiler Chicken Supply Chain and Patients, China, 2010-2016.
Mutation in parC contributes to ciprofloxacin and ofloxacin resistance.
International lineages of Salmonella enterica serovars isolated from chicken farms, Wakiso District, Uganda.
Emergence of a multidrug-resistant ST 27 Escherichia coli co-harboring bla(NDM-1), mcr-1, and fosA3 from a patient in China.
Molecular characterization of metallo-β-lactamase- producing carbapenem-resistant Enterobacter cloacae complex isolated in Heilongjiang Province of China.
Prevalence of fluoroquinolone-resistant Salmonella serotypes in Iran: a meta-analysis.
Mutations in parC were detected in nalidixic acid-resistant isolates.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
Mutations in quinolone resistance-determining region
Fluoroquinolone resistance in complicated urinary tract infections: association with the increased occurrence and diversity of Escherichia coli of clonal complex 131, together with ST1193.
Mutations associated with fluoroquinolone resistance
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
Found in multiple E. coli isolates
Genomic characterization of extended-spectrum beta-lactamase-producing and carbapenem-resistant Escherichia coli from urban wastewater in Australia.
Development of an in vitro biofilm model for the study of the impact of fluoroquinolones on sewer biofilm microbiota.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
A novel variant in Salmonella genomic island 1 of multidrug-resistant Salmonella enterica serovar Kentucky ST198.
Mutations in the quinolone resistance-determining region (QRDR) of parC.
Short reads-based characterization of pathotype diversity and drug resistance among Escherichia coli isolated from patients attending regional referral hospitals in Tanzania.
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy domestic cats.
Serovar and sequence type distribution and phenotypic and genotypic antimicrobial resistance of Salmonella originating from pet animals in Chongqing, China.
Alterations in topoisomerase IV and DNA gyrase in quinolone-resistant mutants of Mycoplasma hominis obtained in vitro.
Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms.
single amino acid change
Fitness cost associated with resistance to fluoroquinolones is diverse across clones of Klebsiella pneumoniae and may select for CTX-M-15 type extended-spectrum β-lactamase.
Fitness benefits in fluoroquinolone-resistant Salmonella Typhi in the absence of antimicrobial pressure.
Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.
Lack of efflux mediated quinolone resistance in Salmonella enterica serovars Typhi and Paratyphi A.
associated with resistance
Molecular analysis of ciprofloxacin resistance mechanisms in Malaysian ESBL-producing Klebsiella pneumoniae isolates and development of mismatch amplification mutation assays (MAMA) for rapid detection of gyrA and parC mutations.
Quinolone resistance mechanisms among extended-spectrum beta-lactamase (ESBL) producing Escherichia coli isolated from rivers and lakes in Switzerland.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
Dynamics of quinolone resistance in fecal Escherichia coli of finishing pigs after ciprofloxacin administration.
Type II and type IV topoisomerase mutations in clinical isolates of Morganella morganii harbouring the qnrD gene.
Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.
Mutations in ParC affect ciprofloxacin binding and activity
Induction of resistant mutants of Salmonella enterica serotype Typhi under ciprofloxacin selective pressure.
Single mutation in parC gene at S80
Fluoroquinolone resistance mechanisms of Shigella flexneri isolated in Bangladesh.
Mutation in parC contributes to fluoroquinolone resistance
Molecular screening for Neisseria gonorrhoeae antimicrobial resistance markers in Nigerian men who have sex with men and transgender women.
Fluoroquinolone resistance in Salmonella: insights by whole-genome sequencing.
chromosomal mutations in parC contribute to fluoroquinolone resistance
Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
Characterizing Mobilized Virulence Factors and Multidrug Resistance Genes in Carbapenemase-Producing Klebsiella pneumoniae in a Sri Lankan Hospital.
Characterization of Klebsiella pneumoniae associated with cattle infections in southwest China using multi-locus sequence typing (MLST), antibiotic resistance and virulence-associated gene profile analysis.
Mutations in parC contribute to ciprofloxacin resistance.
Variant O89 O-Antigen of E. coli Is Associated With Group 1 Capsule Loci and Multidrug Resistance.
Mutation in parC contributes to quinolone resistance.
A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.
Resolution of fluoroquinolone-resistant Escherichia coli keratitis with a PROSE device for enhanced targeted antibiotic delivery.
Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana.
Whole-genome sequences of multidrug-resistant Escherichia coli in South-Kivu Province, Democratic Republic of Congo: characterization of phylogenomic changes, virulence and resistance genes.
Multiple Benefits of Plasmid-Mediated Quinolone Resistance Determinants in Klebsiella pneumoniae ST11 High-Risk Clone and Recently Emerging ST307 Clone.
Resistance and Virulence Mechanisms of Escherichia coli Selected by Enrofloxacin in Chicken
Association of fluoroquinolone resistance, virulence genes, and IncF plasmids with extended-spectrum-β-lactamase-producing Escherichia coli sequence type 131 (ST131) and ST405 clonal groups.
Evaluation of co-transfer of plasmid-mediated fluoroquinolone resistance genes and bla(NDM) gene in Enterobacteriaceae causing neonatal septicaemia.
Mutations in parC contribute to fluoroquinolone resistance.
Mechanisms of reduced susceptibility to ciprofloxacin in Escherichia coli isolates from Canadian hospitals.
Prevalence and mechanism of fluoroquinolone resistance in clinical isolates of Proteus mirabilis in Japan.
Fluoroquinolone-Resistant Salmonella enterica, Campylobacter spp., and Arcobacter butzleri from Local and Imported Poultry Meat in Kumasi, Ghana.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
High prevalence of fluoroquinolone-resistant Escherichia coli strains isolated from urine clinical samples.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
A survey of antimicrobial-resistant Escherichia coli prevalence in wild mammals in Japan using antimicrobial-containing media.
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
Isolation of extended-spectrum β-lactamase-producing Escherichia coli from Japanese red fox (Vulpes vulpes japonica).
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
specific for all phenotypic-resistant isolates
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
Prevalence and whole genome phylogenetic analysis reveal genetic relatedness between antibiotic resistance Salmonella in hatchlings and older chickens from farms in Nigeria.
Molecular characterization of extended-spectrum cephalosporin and fluoroquinolone resistance genes in Salmonella and Shigella isolated from clinical specimens in Thailand.
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
One health clones of multidrug-resistant Escherichia coli carried by synanthropic animals in Brazil.
Nanopore-only assemblies for genomic surveillance of the global priority drug-resistant pathogen, Klebsiella pneumoniae.
An ST131 clade and a phylogroup A clade bearing an O101-like O-antigen cluster predominate among bloodstream Escherichia coli isolates from South-West Nigeria hospitals.
Mutations in parC contribute to fluoroquinolone resistance.
Quinolone-resistant Escherichia coli at the interface between humans, poultry and their shared environment- a potential public health risk.
Single substitution
Whole-Genome Analysis of Antimicrobial-Resistant Salmonella enterica Isolated from Duck Carcasses in Hanoi, Vietnam.
Discovery of a novel sub-lineage of multi-drug resistant Shigella flexneri in Southern California.
chromosomal mutation
Editorial: Mobile genetic elements as dissemination drivers of multidrug-resistant Gram-negative bacteria
Genetic Determinants of Macrolide and Fluoroquinolone Resistance in Mycoplasma genitalium and Their Prevalence in Moscow, Russia.
Genetic characterization of ESBL-producing and ciprofloxacin-resistant Escherichia coli from Belgian broilers and pigs.
Mutations in QRDR of gyrA and parC were found in all ciproR-E. coli.
Genomic characterization of endemic diarrheagenic Escherichia coli and Escherichia albertii from infants with diarrhea in Vietnam.
Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study.
A Nationwide Genomic Study of Clinical Klebsiella pneumoniae Carrying bla(OXA-232) and rmtF in China.
The Prevalence of Multidrug-Resistant Enterobacteriaceae among Neonates in Kuwait.
Genomic Characterization of Uropathogenic Escherichia coli Isolates from Tertiary Hospitals in Riyadh, Saudi Arabia.
Prevalence and Characterization of Extended-Spectrum β-Lactamase-Producing Escherichia coli Isolated from Dogs and Cats in South Korea.
Isolation, susceptibility profiles and genomic analysis of a colistin-resistant Salmonella enterica serovar Kentucky strain COL-R.
mutation in parC gene
Investigation of Delafloxacin Resistance in Multidrug-Resistant Escherichia coli Strains and the Detection of E. coli ST43 International High-Risk Clone.
mutations in QRDR of parC contribute to fluoroquinolone resistance
Uropathogenic Escherichia coli population structure and antimicrobial susceptibility in Norfolk, UK.
Expansion of healthcare-associated hypervirulent KPC-2-producing Klebsiella pneumoniae ST11/KL64 beyond hospital settings.
Founding of the culture collection of antibiotic-resistant strains of zoonotic bacteria in the Russian Federation.
Dissemination of the high-risk cloneST147 carbapenem-resistant klebsiella pneumoniae from a local tertiary care hospital in the Republic of Korea.
Genomic analysis and antimicrobial activity of β-lactam/β-lactamase inhibitors and other agents against KPC-producing Klebsiella pneumoniae clinical isolates from Brazilian hospitals.
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
Mutations in parC confer resistance to fluoroquinolones.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
Multidrug Resistance Profiles and Resistance Mechanisms to β-Lactams and Fluoroquinolones in Bacterial Isolates from Hospital Wastewater in Bangladesh.
Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs.
Species Profiles and Antimicrobial Resistance of Non-aureus Staphylococci Isolated from Healthy Broilers, Farm Environments, and Farm Workers.
Occurrence of a New Variant of Salmonella Infantis Lacking Somatic Antigen.
Chance Favors the Prepared Genomes: Horizontal Transfer Shapes the Emergence of Antibiotic Resistance Mutations in Core Genes.
One of the most frequent mutations in E. coli
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis.
Detection of Salmonella DNA and drug-resistance mutation by PCR-based CRISPR-lbCas12a system.
The S80I mutation in the parC gene was detected in a clinical isolate and confirmed by direct sequencing.
Genomic Analysis of Multidrug-Resistant Escherichia coli Strains Isolated in Tamaulipas, Mexico.
Mutations in the quinolone resistance-determining regions of gyrA and parC in Enterobacteriaceae isolates from Brazil.
Mutations in parC gene are associated with fluoroquinolone resistance.
Fluoroquinolone resistance determinants in carbapenem-resistant Escherichia coli isolated from urine clinical samples in Thailand.
most common mutation
The clinical, genomic, and microbiological profile of invasive multi-drug resistant Escherichia coli in a major teaching hospital in the United Kingdom.
Mutation in parC contributes to ciprofloxacin resistance.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
Mutations in parC contribute to fluoroquinolone resistance.
Emergence and persistent spread of carbapenemase-producing Klebsiella pneumoniae high-risk clones in Greek hospitals, 2013 to 2022.
Genome Analysis of Klebsiella pneumoniae Reveals International High-Risk Pandemic MDR Clones Emerging in Tertiary Healthcare Settings in Uganda.
Word-based GWAS harnesses the rich potential of genomic data for E. coli quinolone resistance.
Escherichia coli sequence type 410 with carbapenemases: a paradigm shift within E. coli toward multidrug resistance.
associated with fluoroquinolone resistance
Genotypic Characterization of Uropathogenic Escherichia coli from Companion Animals: Predominance of ST372 in Dogs and Human-Related ST73 in Cats.
Copy Number Change of the NDM-1 sequence in a multidrug-resistant Klebsiella pneumoniae clinical isolate.
Temporal changes in resistance mechanisms in colonizing Escherichia coli isolates with reduced susceptibility to fluoroquinolones.
Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico.
Susceptibility to β-lactams and quinolones of Enterobacteriaceae isolated from urinary tract infections in outpatients.
Implementation of Whole Genome Sequencing (WGS) for Identification and Characterization of Shiga Toxin-Producing Escherichia coli (STEC) in the United States.
Mutations in parC in combination with mutations in gyrA confer resistance to nalidixic acid and ciprofloxacin.
Multi-Drug Resistance Mediated by Class 1 Integrons in Aeromonas Isolated from Farmed Freshwater Animals.
Molecular characterization and analysis of high-level multidrug-resistance of Shigella flexneri serotype 4s strains from China.
Novel mutations in quinolone resistance-determining regions of gyrA, gyrB, parC and parE in Shigella flexneri clinical isolates from eastern Chinese populations between 2001 and 2011.
Genome Sequence of Kocuria polaris Strain CD08_4, an Isolate from the Duodenal Mucosa of a Celiac Disease Patient.
Emergence of Resistance Mutations in Salmonella enterica Serovar Typhi Against Fluoroquinolones.
Mutation in parC contributes to fluoroquinolone resistance
Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.
Resistome Analysis of a Carbapenemase (OXA-48)-Producing and Colistin-Resistant Klebsiella pneumoniae Strain.
Nonsynonymous mutation in the parC gene
Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.
Less common mutation in quinolone resistant Salmonella.
Out of Asia: the independent rise and global spread of fluoroquinolone-resistant Shigella.
mutations in QRDR region of parC contribute to fluoroquinolone resistance in Shigella
Dominant serotype distribution and antimicrobial resistance profile of Shigella spp. in Xinjiang, China.
Genomic Analysis of a Pan-Resistant Isolate of Klebsiella pneumoniae, United States 2016.
mutation leading to fluoroquinolone resistance
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
Mutations in the QRDR of parC contribute to fluoroquinolone resistance.
Pathogenic potential and the role of clones and plasmids in beta-lactamase-producing E. coli from chicken faeces in Vietnam.
Mutations in the quinolone resistance-determining region (QRDR) of gyrA and parC genes.
Phylogenetic Analysis Indicates a Longer Term Presence of the Globally Distributed H58 Haplotype of Salmonella Typhi in Southern India.
Broad-Spectrum Cephalosporin-Resistant Klebsiella spp. Isolated from Diseased Horses in Austria.
Molecular characterization of quinolone resistant Shigella spp. isolates from patients in Ardabil, Iran.
Emergence of CTX-M-27-producing Escherichia coli of ST131 and clade C1-M27 in an impacted ecosystem with international maritime traffic in South America.
Persistent Asymptomatic Human Infections by Salmonella enterica Serovar Newport in China.
Found in one ST68 isolate.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
Epidemiological Study on Prevalence, Serovar Diversity, Multidrug Resistance, and CTX-M-Type Extended-Spectrum β-Lactamases of Salmonella spp. from Patients with Diarrhea, Food of Animal Origin, and Pets in Several Provinces of China.
The study identified QRDR mutations in GyrA and ParC, including S80I in ParC, which are associated with resistance to quinolones such as ciprofloxacin and nalidixic acid.
Genomic profiling of Escherichia coli isolates from bacteraemia patients: a 3-year cohort study of isolates collected at a Sydney teaching hospital.
Prevalence and Characterization of Plasmid-Mediated Quinolone Resistance Determinants qnr and aac(6')-Ib-cr in Ciprofloxacin-Resistant Escherichia coli Isolates from Commercial Layer in Korea.
Predictable properties of fitness landscapes induced by adaptational tradeoffs.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
Characterizing Antimicrobial Resistant Escherichia coli and Associated Risk Factors in a Cross-Sectional Study of Pig Farms in Great Britain.
Comparative Genome Analyses of Wild Type- and Quinolone Resistant Escherichia coli Indicate Dissemination of QREC in the Norwegian Broiler Breeding Pyramid.
Bird-livestock interactions associated with increased cattle fecal shedding of ciprofloxacin-resistant Escherichia coli within feedlots in the United States.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
Transferable Extended-Spectrum β-Lactamase (ESBL) Plasmids in Enterobacteriaceae from Irrigation Water.
Molecular characteristics of fluoroquinolone-resistant avian pathogenic Escherichia coli isolated from broiler chickens.
Mycoplasma bovis in Spanish Cattle Herds: Two Groups of Multiresistant Isolates Predominate, with One Remaining Susceptible to Fluoroquinolones.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The prevalence and mechanism of fluoroquinolone resistance in Escherichia coli isolated from swine farms in China.
Mutations in the QRDR region
Profiles of gyrA Mutations and Plasmid-Mediated Quinolone Resistance Genes in Shigella Isolates with Different Levels of Fluoroquinolone Susceptibility.
Present in ciprofloxacin-intermediate and ciprofloxacin-resistant isolates.
Complete Genome Assembly of a Multidrug-Resistant New Delhi Metallo-β-Lactamase 1 (NDM-1)-Producing Escherichia coli Human Isolate from a New Zealand Hospital.
The Resistance Mechanism of Mycoplasma bovis From Yaks in Tibet to Fluoroquinolones and Aminoglycosides.
Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
Detection of Antimicrobial Resistance Mechanisms in Third-Generation Cephalosporin and Ciprofloxacin Resistant Salmonella Isolates from Livestock Meat and Human Diarrhea Patients
Genomic and Evolutionary Analysis of Salmonella enterica Serovar Kentucky Sequence Type 198 Isolated From Livestock In East Africa.
Mutations in gyrA and parC confer resistance to ciprofloxacin.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
Enterococcus Virulence and Resistant Traits Associated with Its Permanence in the Hospital Environment.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
Antimicrobial susceptibilities and mechanisms of resistance of commensal and invasive Mycoplasma salivarium isolates.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
Prevalence of Plasmid-Mediated Quinolone Resistance (PMQRs) Determinants and Whole Genome Sequence Screening of PMQR-Producing E. coli Isolated from Men Undergoing a Transrectal Prostate Biopsy.
Molecular analysis of OXA-48-producing Escherichia coli in Switzerland from 2019 to 2020.
Investigation of In Vitro Susceptibility and Resistance Mechanisms in Skin Pathogens: Perspectives for Fluoroquinolone Therapy in Canine Pyoderma.
Acquisition of genomic elements were pivotal for the success of Escherichia coli ST410
Evaluation of Antibiotic Resistance Mechanisms in Gram-Negative Bacteria.
Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel.
Point mutation in quinolone-resistance determining region
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp.
Evaluation of Antimicrobial Resistancein Clinical Isolates of Enterococcus spp. Obtained from Hospital Patients in Latvia.
Genome Sequences of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Recovered from Mid-Stream Urine Samples in Accra, Ghana.
Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.
Genomic and phenotypic inconsistencies in Pseudomonas aeruginosa resistome among intensive care patients.
A microbiological and genomic perspective of globally collected Escherichia coli from adults hospitalized with invasive E. coli disease.
Investigation of gyrA and parC mutations and the prevalence of plasmid-mediated quinolone resistance genes in Klebsiella pneumoniae clinical isolates.
Comparative in vitro activity of Delafloxacin and other antimicrobials against isolates from patients with acute bacterial skin, skin-structure infection and osteomyelitis.
Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.
parC
Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.
parC
Characterisation of novel mutations involved in quinolone resistance in Escherichia coli isolated from imported shrimp.
Escherichia coli parC conferring resistance to fluoroquinolones; CARD accession: CARD:3003308
Unknown phenotype if each mutation occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations
Activity of quinolones against gram-positive cocci: mechanisms of drug action and bacterial resistance.
Surgical treatment for anomalous origin of left coronary artery from pulmonary artery.
Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene.
Unknown phenotype if each mutation occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations
Unknown phenotype if each mutation occurs alone. Nalidixic acid and ciprofloxacin resistance when associated with gyrA mutations
High prevalence of acquired quinolone-resistance genes among Enterobacteriaceae from Saudi Arabia with CTX-M-15 β-lactamase.
Under development. Phenotype should be used with caution.
Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.
Brushstrokes and scalpels.
Comparative genomic analysis of Acinetobacter baumannii clinical isolates reveals extensive genomic variation and diverse antibiotic resistance determinants.
Whole-genome sequencing of Shigella for surveillance purposes shows (inter)national relatedness and multidrug resistance in isolates from men who have sex with men.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
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