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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations blaNDM-1TGC->GCA

Nucleotide ChangeTGC->GCA

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced catalytic efficiency and stability
Resistance To: Ampicillin|Cefotaxime|Ceftazidime|Cefoxitin|Imipenem|Meropenem
Organisms: Enterobacter cloacae, Escherichia coli
Papers: 1

Paper Information1

1

Role of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1.

PMID 26525789 · 2016

Trp-93 mutation leads to reduced resistance

Mutation Information

blaNDM-1: c.TGC->GCA

Nucleotide Change: TGC->GCA
Organisms: Enterobacter cloacae, Escherichia coli
Confers Resistance To: Ampicillin|Cefotaxime|Ceftazidime|Cefoxitin|Imipenem|Meropenem

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

reduced catalytic efficiency and stability

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research