ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeT69S

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: allows activation independent of VanS
Resistance To: Glycopeptide
Organisms: Streptomyces coelicolor, Streptomyces toyocaensis
Papers: 1

Paper Information1

In Vivo Characterization of the Activation and Interaction of the VanR-VanS Two-Component Regulatory System Controlling Glycopeptide Antibiotic Resistance in Two Related Streptomyces Species.

PMID 26711760 · 2015

The T69S mutation in the REC domain of VanRst allows activation independent of VanS.

Mutation Information

vanR: p.T69S

Protein Change: T69S
Organisms: Streptomyces coelicolor, Streptomyces toyocaensis
Confers Resistance To

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Mutation Information