ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneacrB

subunit of the AcrAB-TolC efflux pump

Protein ChangeI38F

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Linezolid|Chloramphenicol|Cefuroxime|Oxacillin|Clindamycin|Tetracycline|Tigecycline|Levofloxacin|Novobiocin
Organisms: Escherichia coli
Papers: 1

Paper Information1

Evidence of a Substrate-Discriminating Entrance Channel in the Lower Porter Domain of the Multidrug Resistance Efflux Pump AcrB.

PMID 27161641 · 2016

Mutations at I38 and I671 in the lower porter domain of AcrB alter substrate specificity, increasing susceptibility to lower molecular weight drugs while maintaining or enhancing resistance to higher molecular weight drugs.

Mutation Information

acrB: p.I38F

Protein Change: I38F
Organisms: Escherichia coli

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Mutation Information