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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations thyAV261G

GenethyA

folate-dependent thymidylate synthase

Protein ChangeV261G

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.
Resistance To: Para-aminosalicylic acid
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Analysis of mutations leading to para-aminosalicylic acid resistance in Mycobacterium tuberculosis.

PMID 31541138 · 2019

Mutations in thyA were associated with para-aminosalicylic acid resistance.

Mutation Information

Protein Change: V261G
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Para-aminosalicylic acid

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

The mutation leads to changes in the dUMP and MTHF binding sites, weak interaction of ThyA enzyme with dUMP and MTHF, loss of hydrogen bond and other atomic interactions, and enhanced movement of protein atoms.

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research