Home Browse Genes Browse Mutations Download Collaborators About

Browse AMR Mutations

Explore antimicrobial resistance mutations from the literature

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research

Home Browse Genes Browse Mutations Download Collaborators About

Browse Mutations Rv0678Q22L

protein

Protein ChangeQ22L

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Bedaquiline|Clofazimine
Organisms: Mycobacterium tuberculosis
Papers: 1

Paper Information1

1

Clofazimine Exposure In Vitro Selects Efflux Pump Mutants and Bedaquiline Resistance

PMID 30642938 · 2019

Mutations in rv0678 lead to overexpression of the mmpL5-mmpS5 efflux pump, causing cross-resistance to bedaquiline and clofazimine.

Mutation Information

Protein Change: Q22L
Organisms: Mycobacterium tuberculosis
Confers Resistance To: Bedaquiline|Clofazimine
Source Database: Reslit

Comments (0)

No comments yet. Be the first to comment!

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research