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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations dfrBW38F

GenedfrB

dihydrofolate reductase

Protein ChangeW38F

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: impedes the formation of functional tetramer, resulting in 10- and 40-fold weaker effective binding to DHF and NADPH, respectively, and a 100-fold reduced catalytic turnover
Resistance To: Trimethoprim
Organisms: E. coli
Papers: 1

Paper Information1

1

A conserved SH3-like fold in diverse putative proteins tetramerizes into an oxidoreductase providing an antimicrobial resistance phenotype.

PMID 36633286 · 2023

Mutation Information

Protein Change: W38F
Organisms: E. coli
Confers Resistance To: Trimethoprim

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

impedes the formation of functional tetramer, resulting in 10- and 40-fold weaker effective binding to DHF and NADPH, respectively, and a 100-fold reduced catalytic turnover

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Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research