ResLit - Antimicrobial Resistance Gene & Mutation Database

GeneclpP

proteolytic regulatory protein

Protein ChangeG94D

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: eliminates proteolytic activity of ClpP
Resistance To: Daptomycin|Vancomycin|Oxacillin
Organisms: Staphylococcus aureus
Papers: 1

Paper Information1

A Clinically Selected Staphylococcus aureus clpP Mutant Survives Daptomycin Treatment by Reducing Binding of the Antibiotic and Adapting a Rod-Shaped Morphology.

PMID 37184389 · 2023

The G94D substitution in ClpP was shown to eliminate proteolytic activity of ClpP.

Mutation Information

clpP: p.G94D

Protein Change: G94D
Organisms: Staphylococcus aureus
Confers Resistance To

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Mutation Information