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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations acrBV448E

GeneacrB

subunit of the AcrAB-TolC efflux pump

Protein ChangeV448E

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduces efflux pump activity
Resistance To: Fluoroquinolones
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

1

Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae.

PMID 38177534 · 2024

The V448E mutation in AcrB reduces efflux pump activity, leading to increased susceptibility to levofloxacin.

Mutation Information

Protein Change: V448E
Organisms: Klebsiella pneumoniae
Confers Resistance To: Fluoroquinolones

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

reduces efflux pump activity

Source Database

Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research