ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeR164W

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: increased resistance to extended-spectrum cephalosporins and β-lactam-β-lactamase inhibitor combinations
Resistance To: cefotaxime|amoxicillin-clavulanate
Organisms: Escherichia coli
Papers: 1

Paper Information1

Haemophilus influenzae blaROB-1 Mutations in Hypermutagenic ΔampC Escherichia coli Conferring Resistance to Cefotaxime and β-Lactamase Inhibitors and Increased Susceptibility to Cefaclor.

PMID 12878518 · 2003

Mutations in blaROB-1 confer resistance to cefotaxime and amoxicillin-clavulanate, but decrease cefaclor hydrolysis.

Mutation Information

blaROB-1: p.R164W

Protein Change: R164W
Organisms: Escherichia coli
Confers Resistance To

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Mutation Information