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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations ddlF258Y

Geneddl

d-Ala-d-Ala ligase

Protein ChangeF258Y

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: reduced vancomycin resistance, increases vancomycin sensitivity
Resistance To: Vancomycin
Organisms: Lactobacillus reuteri, Lactobacillus plantarum
Papers: 2

Paper Information2

1

High efficiency recombineering in lactic acid bacteria.

PMID 22328729 · 2012

mutation in active site reduces vancomycin resistance

Mutation Information

ddl: p.F258Y / c.TTA->TAC

Protein Change: F258Y
Nucleotide Change: TTA->TAC
Organisms: Lactobacillus reuteri
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Vancomycin

Effect on Function

reduced vancomycin resistance

Source Database

Reslit

2

d-Alanyl-d-Alanine Ligase as a Broad-Host-Range Counterselection Marker in Vancomycin-Resistant Lactic Acid Bacteria.

PMID 29686137 · 2018

Mutations in Ddl lead to decreased vancomycin resistance by altering peptidoglycan structure.

Mutation Information

Protein Change: F258Y
Organisms: Lactobacillus plantarum, Lactobacillus reuteri
Confers Resistance To: Vancomycin
Effect on Function: increases vancomycin sensitivity
Source Database: Reslit

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research