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Browse Mutations gyrBD464N

GenegyrB

Protein ChangeD464N

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReslit

Overview

Mechanism: single resistance variant
Resistance To: Ofloxacin|Moxifloxacin|Sitafloxacin|Ciprofloxacin|Levofloxacin, Fluoroquinolones
Organisms: Mycobacterium leprae
Papers: 1

Paper Information1

1

Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance.

PMID 23071850 · 2012

Mutations in gyrB contribute to fluoroquinolone resistance in M. leprae.

Mycobacterium leprae gyrB conferring resistance to fluoroquinolones; CARD accession: CARD:3003304

Mutation Information

gyrB: p.D464N / c.GAT->AAT

Protein Change: D464N
Nucleotide Change: GAT->AAT

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Organisms

Mycobacterium leprae

Confers Resistance To

Ofloxacin|Moxifloxacin|Sitafloxacin|Ciprofloxacin|LevofloxacinFluoroquinolones

Effect on Function

single resistance variant

Source Database

ReslitCard Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research