gyrB
Overview
- Papers
- 17
- Mutations
- 24
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| K447E | - | Target modification | Escherichia coli | Nalidixic acid | ResFinder | Established |
| A436T | - | - | Pseudomonas aeruginosa | ciprofloxacin|garenoxacin | Reslit | Candidate |
| R445S | - | - | Streptococcus pneumoniae | clinafloxacin|ciprofloxacin|trovafloxacin | Reslit | Candidate |
| G406S | - | - | Streptococcus pneumoniae | clinafloxacin|ciprofloxacin|trovafloxacin | Reslit | Candidate |
| D426N | - | Target modification | Clostridium difficile, Escherichia coli | Ciprofloxacin|Moxifloxacinmoxifloxacin|ciprofloxacin|gatifloxacin|levofloxacinmoxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin+1 more | ResFinderReslit | Confirmed |
| S464F | - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate |
| A473V | - | - | Pseudomonas aeruginosa | ciprofloxacin|garenoxacin | Reslit | Candidate |
| R379L | - | - | Streptococcus pneumoniae | fluoroquinolones | Reslit | Candidate |
| S416A | - | - | Clostridium difficile | moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacin | Reslit | Candidate |
| D426V | - | - | Clostridium difficile | moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacinmoxifloxacin|levofloxacin | Reslit | Candidate |
| R447K | - | - | Clostridium difficile | moxifloxacin|ciprofloxacin|levofloxacinmoxifloxacin|levofloxacin | Reslit | Candidate |
| Y87F | - | - | E. coli | norfloxacin | Reslit | Candidate |
| E466D | - | - | Salmonella enterica | ciprofloxacin | Reslit | Candidate |
| E117G | - | - | - | fluoroquinolones | Reslit | Candidate |
| N473D | - | - | Streptococcus pneumoniae | moxifloxacin|levofloxacin|gemifloxacin | Reslit | Candidate |
| R447L | - | - | Clostridium difficile | Ciprofloxacin|Moxifloxacin | Reslit | Candidate |
| - | - | Salmonella enterica | fluoroquinolones | Reslit | Candidate | |
| - | - | Salmonella enterica | fluoroquinolones | Reslit | Candidate | |
| - | - | Salmonella enterica | fluoroquinolones | Reslit | Candidate | |
| - | - | Salmonella enterica | fluoroquinolones | Reslit | Candidate | |
| - | - | Salmonella enterica | fluoroquinolones | Reslit | Candidate | |
| - | - | Escherichia coli | ciprofloxacin|norfloxacin | Reslit | Candidate | |
| E466K | - | Clostridium difficile | moxifloxacin | Reslit | Candidate | |
| E512D | - | Mycobacterium tuberculosis | fluoroquinolones | Reslit | Candidate |
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli.
Mutation Information
- Protein Change
- K447E, D426N
- Organisms
- Escherichia coli
- Confers Resistance To
- Nalidixic acidNalidixic acid,Ciprofloxacin
- Effect on Function
- Target modification
- Source Database
- ResFinder
Selection of cross-resistance following exposure of Pseudomonas aeruginosa clinical isolates to ciprofloxacin or cefepime.
Mutation Information
- Protein Change
- A436T, A473V
- Organisms
- Pseudomonas aeruginosa
- Confers Resistance To
- ciprofloxacin|garenoxacin
- Source Database
- Reslit
In vitro selection of resistance to clinafloxacin, ciprofloxacin, and trovafloxacin in Streptococcus pneumoniae.
Mutation Information
- Protein Change
- R445S, G406S
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- clinafloxacin|ciprofloxacin|trovafloxacin
- Source Database
- Reslit
gyrA and gyrB Mutations Are Implicated in Cross-Resistance to Ciprofloxacin and Moxifloxacin in Clostridium difficile.
Mutation Information
- Protein Change
- D426N, R447L
- Organisms
- Clostridium difficile
- Confers Resistance To
- Ciprofloxacin|Moxifloxacin
- Source Database
- Reslit
Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans.
Mutation Information
- Protein Change
- S464F
- Organisms
- Salmonella enterica
- Confers Resistance To
- ciprofloxacin
- Source Database
- Reslit
Horizontal transfer of fluoroquinolone resistance genes in Streptococcus pneumoniae
Mutation in gyrB is associated with fluoroquinolone resistance.
Mutation Information
- Protein Change
- R379L
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
Fluoroquinolone resistance in Clostridium difficile isolates from a prospective study of C. difficile infections in Europe.
Two new substitutions for C. difficile, Ser416Ala and Arg447Lys, were found in GyrB.
Mutation Information
- Protein Change
- S416A, D426N, D426V, R447K
- Organisms
- Clostridium difficile
- Confers Resistance To
- moxifloxacin|ciprofloxacin|gatifloxacin|levofloxacinmoxifloxacin|ciprofloxacin|levofloxacin
- Source Database
- Reslit
Sublethal antibiotic treatment leads to multidrug resistance via radical-induced mutagenesis.
Mutation Information
- Protein Change
- Y87F
- Organisms
- E. coli
- Confers Resistance To
- norfloxacin
- Source Database
- Reslit
Multiple regulatory pathways associated with high-level ciprofloxacin and multidrug resistance in Salmonella enterica serovar enteritidis: involvement of ramA and other global regulators.
Novel mutation in 5408-cip.
Mutation Information
- Protein Change
- E466D
- Organisms
- Salmonella enterica
- Confers Resistance To
- ciprofloxacin
- Source Database
- Reslit
Molecular analysis of the gyrA and gyrB quinolone resistance-determining regions of fluoroquinolone-resistant Clostridium difficile mutants selected in vitro.
Mutation Information
- Protein Change
- D426V, R447K
- Organisms
- Clostridium difficile
- Confers Resistance To
- moxifloxacin|levofloxacin
- Source Database
- Reslit
A novel mechanism of transposon-mediated gene activation.
Mutation in gyrB was shown to contribute to fluoroquinolone resistance.
Mutation Information
- Protein Change
- E117G
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci.
mutation in quinolone resistance-determining region associated with resistance to fluoroquinolones
Mutation Information
- Protein Change
- N473D
- Organisms
- Streptococcus pneumoniae
- Confers Resistance To
- moxifloxacin|levofloxacin|gemifloxacin
- Source Database
- Reslit
Clostridium difficile Isolates Resistant to Fluoroquinolones in Italy: Emergence of PCR Ribotype 018
Mutation in gyrB confers resistance to fluoroquinolones
Mutation Information
- Protein Change
- D426N
- Organisms
- Clostridium difficile
- Confers Resistance To
- moxifloxacin|ciprofloxacin|levofloxacin|gatifloxacin
- Source Database
- Reslit
A multiplex single nucleotide polymorphism typing assay for detecting mutations that result in decreased fluoroquinolone susceptibility in Salmonella enterica serovars Typhi and Paratyphi A.
Mutations in gyrB are associated with decreased fluoroquinolone susceptibility.
Mutation Information
- Nucleotide Change
- A1394C, A1394T, A1398C, C1391T, C1398A
- Organisms
- Salmonella enterica
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit
Mechanisms accounting for fluoroquinolone resistance in Escherichia coli clinical isolates.
Mutation Information
- Nucleotide Change
- G1373A
- Organisms
- Escherichia coli
- Confers Resistance To
- ciprofloxacin|norfloxacin
- Source Database
- Reslit
Effects of exposure of Clostridium difficile PCR ribotypes 027 and 001 to fluoroquinolones in a human gut model.
Mutation present in three C. difficile PCR ribotype 027 isolates with raised moxifloxacin MIC.
Mutation Information
- Protein Change
- E466K
- Nucleotide Change
- G1397A
- Organisms
- Clostridium difficile
- Confers Resistance To
- moxifloxacin
- Source Database
- Reslit
In vivo validation of the mutant selection window hypothesis with moxifloxacin in a murine model of tuberculosis.
Detected in mice treated with 0.25% MXF
Mutation Information
- Protein Change
- E512D
- Nucleotide Change
- G1537T
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- fluoroquinolones
- Source Database
- Reslit