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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations amgSR182C

GeneamgS

Protein ChangeR182C

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: gain-of-function mutation that activates the AmgRS two-component system, two-component system sensor histidine kinase AmgS
Resistance To: Tobramycin|Gentamicin|Amikacin|Paromomycin|Neomycin|Streptomycin, AMIKACIN/TOBRAMYCIN
Organisms: Pseudomonas aeruginosa
Papers: 2

Paper Information2

1

Mutational activation of the AmgRS two-component system in aminoglycoside-resistant Pseudomonas aeruginosa.

PMID 23459488 · 2013

The R182C mutation in amgS was shown to activate the AmgRS two-component system, leading to increased resistance to aminoglycosides.

amgS

Mutation Information

Protein Change: R182C
Organisms: Pseudomonas aeruginosa
Confers Resistance To

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Tobramycin|Gentamicin|Amikacin|Paromomycin|Neomycin|StreptomycinAMIKACIN/TOBRAMYCIN

Effect on Function

gain-of-function mutation that activates the AmgRS two-component system; two-component system sensor histidine kinase AmgS

Source Database

ReslitReference Gene Catalog

2

[Overview of the Swiss Red Cross service activities in professional education].

PMID 254508 · 1979

amgS

Mutation Information

Protein Change: R182C
Organisms: Pseudomonas aeruginosa
Confers Resistance To: AMIKACIN/TOBRAMYCIN
Effect on Function: two-component system sensor histidine kinase AmgS
Source Database: Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research