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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations clsA20D

Genecls

cardiolipin synthetase

Protein ChangeA20D

Validation StatusConfirmed2+ DBs

Databases

Card DatabaseReference Gene CatalogReslit

Overview

Mechanism: alter phospholipid biosynthesis and decrease bacterial susceptibility, cardiolipin synthase Cls, single resistance variant
Resistance To: Daptomycin, DAPTOMYCIN
Organisms: Enterococcus faecium
Papers: 4

Paper Information4

1

Evolution and mutations predisposing to daptomycin resistance in vancomycin-resistant Enterococcus faecium ST736 strains.

PMID 30576392 · 2018

Mutation Information

cls: p.A20D / c.G60A

Protein Change: A20D
Nucleotide Change: G60A
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Source Database

Reslit

2

Last Bacteria Standing: VREfm Persistence in the Hospitalized Gut.

PMID 35762592 · 2022

Mutation Information

Protein Change: A20D
Organisms: Enterococcus faecium
Confers Resistance To: Daptomycin
Effect on Function: alter phospholipid biosynthesis and decrease bacterial susceptibility
Source Database: Reslit

3

Emergence of daptomycin non-susceptibility in colonizing vancomycin-resistant Enterococcus faecium isolates during daptomycin therapy.

PMID 26454536 · 2015

cls

Enterococcus faecium cls conferring resistance to daptomycin; CARD accession: CARD:3003092

Mutation Information

Protein Change: A20D
Organisms: Enterococcus faecium
Confers Resistance To: DAPTOMYCINDaptomycin
Effect on Function: cardiolipin synthase Cls; single resistance variant
Source Database: Reference Gene CatalogCard Database

4

Role of compression modalities in a prophylactic program for deep vein thrombosis.

PMID 3057639 · 1988

cls

Mutation Information

Protein Change: A20D
Organisms: Enterococcus faecium
Confers Resistance To: DAPTOMYCIN
Effect on Function: cardiolipin synthase Cls
Source Database: Reference Gene Catalog

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research