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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations dfrBF99S

GenedfrB

dihydrofolate reductase

Protein ChangeF99S

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder Database

Overview

Mechanism: dihydrofolate reductase DfrB, Target modification
Resistance To: TRIMETHOPRIM, Trimethoprim
Organisms: Staphylococcus aureus
Papers: 2

Paper Information2

1

Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques.

PMID 19383727 · 2009

Mutation Information

Protein Change: F99S
Organisms: Staphylococcus aureus
Confers Resistance To: Trimethoprim

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

Target modification

Source Database

ResFinder Database

2

Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.

PMID 22491688 · 2012

Mutation Information

Protein Change: F99S
Organisms: Staphylococcus aureus
Confers Resistance To: Trimethoprim
Effect on Function: Target modification
Source Database: ResFinder Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research