ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeF198L

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogReslit

Overview

Mechanism: loss of function, efflux system transcriptional repressor NalD
Resistance To: Aztreonam, AZTREONAM/CARBAPENEM/CHLORAMPHENICOL/TETRACYCLINE/VABORBACTAM
Organisms: Pseudomonas aeruginosa
Papers: 1

Paper Information1

Systems-level analysis of NalD mutation, a recurrent driver of rapid drug resistance in acute Pseudomonas aeruginosa infection.

The F198L mutation in NalD was shown to confer aztreonam resistance by derepressing the mexAB-oprM efflux system.

Mutation in NalD leads to loss of function and overexpression of MexAB-OprM efflux system.

nalD

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