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Browse Mutations tet(X4)L282S

tigecycline-modifying enzyme

Protein ChangeL282S

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: enhanced catalytic efficiency
Resistance To: Tigecycline
Organisms: E. coli
Papers: 1

Paper Information1

1

Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline.

PMID 34895224 · 2021

These mutations enhance catalytic efficiency and resistance to tigecycline.

Mutation Information

tet(X4): p.L282S

Protein Change: L282S
Organisms: E. coli
Confers Resistance To: Tigecycline

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Effect on Function

enhanced catalytic efficiency

Source Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research