ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp1b

penicillin-binding protein

Protein ChangeT491N

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac
Resistance To: Vancomycin
Organisms: Enterococcus faecalis
Papers: 1

Paper Information1

Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis.

PMID 40007607 · 2025

The threonine-to-asparagine substitution at position 491 in PBP1B leads to a shift in substrate preference from D-Ala-D-Ala to D-Ala-D-Lac.

Mutation Information

pbp1b: p.T491N

Protein Change: T491N
Organisms: Enterococcus faecalis
Confers Resistance To

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Mutation Information