ResLit - Antimicrobial Resistance Gene & Mutation Database

Protein ChangeL58P

Validation StatusCandidate

Databases

Reslit

Overview

Mechanism: disrupt the binding affinity of RamR to the ramA promoter
Resistance To: Eravacycline|Tetracycline|Tigecycline|Minocycline|Levofloxacin|Ceftazidime|Cefepime|Cefoxitin|Imipenem|Meropenem|Piperacillin/tazobactam|Ceftolozane/tazobactam|Aztreonam|Colistin|Ertapenem|Ampicillin/sulbactam|Imipenem/relebactam
Organisms: Klebsiella pneumoniae
Papers: 1

Paper Information1

Dual role of ramR mutation in enhancing immune activation and elevating eravacycline resistance in Klebsiella pneumoniae.

mutations in ramR lead to upregulation of efflux pumps

Protein Change: L58P
Organisms: Klebsiella pneumoniae
Confers Resistance To: Eravacycline|Tetracycline|Tigecycline|Minocycline|Levofloxacin|Ceftazidime|Cefepime|Cefoxitin|Imipenem|Meropenem|Piperacillin/tazobactam|Ceftolozane/tazobactam|Aztreonam|Colistin|Ertapenem|Ampicillin/sulbactam|Imipenem/relebactam

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