ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp2b

penicillin-binding protein 2B

Protein ChangeE476G

Nucleotide ChangeA1427G

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Penicillin|Cefotaxime
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

PMID 15980366 · 2005

Mutations T446A, E476G, and T489S in PBP 2b are associated with reduced susceptibility to penicillin G and cefotaxime.

Mutation Information

pbp2b: p.E476G / c.A1427G

Protein Change: E476G
Nucleotide Change: A1427G
Organisms

Browse AMR Mutations

Mutation Information