ResLit - Antimicrobial Resistance Gene & Mutation Database

Genepbp1b

penicillin-binding protein

Protein ChangeM527L

Nucleotide ChangeA1580C

Validation StatusCandidate

Databases

Reslit

Overview

Resistance To: Penicillin|Cefotaxime
Organisms: Streptococcus pneumoniae
Papers: 1

Paper Information1

Identical penicillin-binding domains in penicillin-binding proteins of Streptococcus pneumoniae clinical isolates with different levels of beta-lactam resistance.

PMID 15980366 · 2005

Mutations N531K, R526S, and M527L in PBP 1b are associated with reduced susceptibility to penicillin G and cefotaxime.

Mutation Information

pbp1b: p.M527L / c.A1580C

Protein Change: M527L
Nucleotide Change: A1580C
Organisms

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Mutation Information