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© 2026 ResLit. Data sourced from PubMed literature analysis.

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Browse Mutations parCT66I

GeneparC

Protein ChangeT66I

Nucleotide ChangeC199T

Validation StatusConfirmed2+ DBs

Databases

Reference Gene CatalogResFinder DatabaseReslit

Overview

Mechanism: DNA topoisomerase IV subunit A ParC, Target modification
Resistance To: Nalidixic acid|Ciprofloxacin, QUINOLONE, Nalidixic acid,Ciprofloxacin
Organisms: Escherichia coli, Salmonella enterica
Papers: 3

Paper Information3

1

Quinolone resistance in Escherichia coli from Accra, Ghana.

PMID 21352598 · 2011

Mutation Information

parC: p.T66I / c.C199T

Protein Change: T66I
Nucleotide Change: C199T
Organisms: Escherichia coli
Confers Resistance To: Nalidixic acid|Ciprofloxacin

ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

Source Database

Reslit

2

Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.

PMID 15848289 · 2005

parC

Mutation Information

Protein Change: T66I
Organisms: Salmonella enterica
Confers Resistance To: QUINOLONE
Effect on Function: DNA topoisomerase IV subunit A ParC
Source Database: Reference Gene Catalog

3

Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.

PMID 15388468 · 2004

Mutation Information

Protein Change: T66I
Organisms: Salmonella enterica
Confers Resistance To: Nalidixic acid,Ciprofloxacin
Effect on Function: Target modification
Source Database: ResFinder Database

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© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research